AUTHOR'S REPLY

S. Poletajew, C. Torz, P. Radziszewski
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Abstract

Cent European J Urol 2015; 68: 17 doi: 10.5173/ceju.2015.01.r95 Although bladder tumors can be considered as a common disease by any experienced urologist, their management remains a challenge for anyone trying to take into account every new study or additional data which continually brings significant changes. Our study was focused on evaluating the delay between the last TURBT and radical cystectomy (RC) in several countries, even though some of the causes of this sometime long delay were not entirely analyzed [1]. It is, however, obvious that there is no standardized approach to the surgical treatment of bladder cancer, probably due to many conflicting data on different therapies. Our original paper was born from the idea that a shorter time between endoscopy and radical surgery is beneficial for the patient and so we decided to get real life data on how this aspect was managed in our countries. There seems to be a consensus that a 3 months interval remains safe for performing a cystectomy, but even this parameter is challenged by some authors [2]. There are many reasons leading to this delay, some of them being beyond the borders of medical science, and so we will not comment on those. But considering some medical reasons that might induce a delay, two major situations appear to be more frequent. The first aspect is the neoadjuvant chemotherapy, recommended by the guidelines as an option, regardless of the stage or other features of the tumor. There are many ongoing studies trying to revolutionize the treatment of bladder cancer by imposing a neoadjuvant chemotherapy as a mandatory step before radical surgery [3], but such evidence needs a long period of time to maCristian Persu1, Sławomir Poletajew2
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欧共体杂志2015;[68] 17 doi: 10.5173/ceju.2015.01。r95尽管任何有经验的泌尿科医生都认为膀胱肿瘤是一种常见病,但对于任何试图考虑每一项新的研究或不断带来重大变化的额外数据的人来说,膀胱肿瘤的治疗仍然是一个挑战。我们的研究重点是评估几个国家最后一次TURBT和根治性膀胱切除术(RC)之间的延迟,尽管这种有时长时间延迟的一些原因并没有完全分析[10]。然而,很明显,膀胱癌的手术治疗没有标准化的方法,可能是由于不同治疗方法的许多相互矛盾的数据。我们最初的论文源于这样一种想法,即缩短内镜检查和根治性手术之间的时间对患者有益,因此我们决定获取现实生活中的数据,了解我们国家在这方面的管理情况。似乎有一个共识,即3个月的间隔时间仍然是安全的进行膀胱切除术,但甚至这个参数被一些作者质疑。导致这种延迟的原因有很多,其中一些原因超出了医学科学的范围,因此我们不会对此发表评论。但考虑到一些可能导致延迟的医疗原因,两种主要情况似乎更常见。第一个方面是新辅助化疗,指南推荐作为一种选择,无论肿瘤的分期或其他特征。有许多正在进行的研究试图通过将新辅助化疗作为根治性手术前的强制性步骤来彻底改变膀胱癌的治疗方法[b],但这些证据需要很长一段时间才能得到证实
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