The Effect of Halofuginone Use on Epidural Fibrosis After Spinal Surgery: An Animal Experiment.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Turkish neurosurgery Pub Date : 2024-01-01 DOI:10.5137/1019-5149.JTN.42998-22.3

Mehmet Zeki Yildiz, Baris Peker, Tugrul Cem Unal, Ilyas Dolas, Cafer Ikbal Gulsever, Duygu Dolen, Evren Sonmez, Yavuz Aras, Aydin Aydoseli, Pulat Akin Sabanci, Altay Sencer, Ali Nail Izgi

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Abstract

Aim: To investigate the effectiveness of local halofuginone application for spinal epidural fibrosis (EF) after lumbar laminectomy in rats.

Material and methods: Forty rats were equally divided into four groups (Groups I-IV; 10 rats in each group), and lumbar laminectomy was performed under general anesthesia. After laminectomy, Group I received saline (NaCl 0.9%) locally (control), Group II received spongostan, Group III received 0.5 mL of halofuginone-impregnated spongostan, and Group IV received 0.5 mL of halofuginone. Spongostan was used to prolong the exposure period of halofuginone. All rats were sacrificed after four weeks and evaluated according to histopathological criteria. A p-value of < 0.05 was considered statistically significant.

Results: Fibrosis was significantly lower in Group IV than in Group I (p < 0.05). There was no significant difference in fibrosis between Group II/III and Group I. It was observed that spongostan increased fibrosis.

Conclusion: Halofuginone helps prevent EF after spinal surgery. However, further clinical and experimental studies are needed to assess its safety in humans.

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使用卤夫酮对脊柱手术后硬膜外纤维化的影响：动物实验

目的：硬膜外纤维化（EF）可导致脊柱手术后持续性腰背痛。I 型胶原是脊柱手术后形成的瘢痕组织的主要成分，因此需要一种抗纤维化药物来防止纤维化。卤夫酮是一种对 I 型胶原蛋白有作用的抗纤维化药物。我们的研究旨在探讨大鼠腰椎板切除术后局部应用卤夫酮对脊柱EF的有效性：将 40 只大鼠平均分为四组（I-IV 组，每组 10 只），在全身麻醉下进行腰椎椎板切除术。椎板切除术后，Ⅰ组大鼠局部接受生理盐水（NaCl 0.9%）（对照组），Ⅱ组大鼠接受斯邦戈司坦，Ⅲ组大鼠接受 0.5 mL 的卤夫酮浸渍斯邦戈司坦，Ⅳ组大鼠接受 0.5 mL 的卤夫酮。斯邦斯坦用于延长哈罗芬酮的暴露期。所有大鼠均在四周后处死，并根据组织病理学标准进行评估。P值为0.05时具有统计学意义：结果：第四组的纤维化程度明显低于第一组（P 0.05）。第二组/第三组与第一组的纤维化程度无明显差异：结论：卤夫酮有助于预防脊柱手术后的 EF。结论：卤虫丙酮有助于预防脊柱手术后的 EF，但还需要进一步的临床和实验研究来评估其对人体的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.