Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients

J. Menczer, L. Schreiber, E. Berger, T. Levy
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Abstract

Uterine serous carcinoma (USC) represents only about 10% of endometrial cancer cases. It is an aggressive tumor with a poor prognosis that is diagnosed in advanced stages in about 40% of the cases and it accounts for a disproportionate number of uterine cancer-related deaths. Even in apparent clinical early stage disease, USC is found to have unfavorable pathological prognostic factors such as lymphovascular space invasion, lymph node involvement, and microscopic intraperitoneal spread [1,2].
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CA125在子宫浆液性癌组织及血清中的表达
子宫浆液性癌(USC)仅占子宫内膜癌病例的10%左右。它是一种侵袭性肿瘤,预后差,约40%的病例在晚期被诊断出来,它占子宫癌相关死亡人数的比例不成比例。即使在明显的临床早期疾病中,USC也被发现有不利的病理预后因素,如淋巴血管间隙侵犯、淋巴结累及和显微镜下的腹腔内扩散[1,2]。
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