{"title":"Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia","authors":"M. Zamecnik, Karol Macuch","doi":"10.5455/JIHP.20170326021845","DOIUrl":null,"url":null,"abstract":"An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"1 1","pages":"1"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of interdisciplinary histopathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/JIHP.20170326021845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.
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