Adenocarcinoma Lung Diagnosed as a ‘Synchronous Primary Double Malignancy’ in Treated Case of Carcinoma of Breast: Case Report

Abstract

Double primary malignancies are rarely observed in breast malignancy, and frequently documented in hematological and gynecological malignancies due to genetic mutations. In present case report, 48-year female presented with left breast carcinoma undergone surgical treatment and received first chemotherapy cycle. Her general health deteriorated and present in our center due to worsened dyspnea. Her radiological workup shown possible metastatic lung process from on treatment carcinoma left breast as classically described ‘bilateral cannon ball’ opacities with middle lobe lung mass. Bronchoscopy was done in critical care unit with oxygen supplementation in sick health after clinical stability. Bronchoscopy workup documented Lung adenocarcinoma. Immunohistochemistry confirmed as Primary lung adenocarcinoma with EGFR positivity. Palliative care was offered due to poor performance status and EGFR targeted therapy was initiated. In this case report we have documented concurrent occurrence of carcinoma breast and adenocarcinoma lung as double primary malignancy.