A Critique of Recent Medical Research in JAMA on COVID-19
M. McAleer
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McAleer","doi":"10.47654/v25y2021i1p40-142","DOIUrl":null,"url":null,"abstract":"The world community has been changed irrevocably by the highly infectious and mutating SARSCoV-2 virus that causes the COVID-19 disease The necessary research output on COVID-19 has been revolutionary, especially in the medical and biomedical sciences, where the search for a vaccine is essential for the world to have a semblance of normality in the era of COVID-19 Much of the advanced research has been distributed in the leading medical journals, including the Journal of the American Medical Association (JAMA), where the latest medical research is distributed on a daily basis, and where comments can also be published The purpose of this paper is to provide a critique of 110 interesting and highly topical research papers that have been published in JAMA, mostly within the past two months The diverse topics include: treating influenza and COVID-19 simultaneously, dealing with a second wave of COVID-19 in Beijing, honesty is best for known and unknown GAWI and WIST, unreliability of asymptomatic COVID-19 testing outcomes for children, the effectiveness of flu vaccines, acute anxiety during COVID-19, MAID as an end of life option, longer-term effects of corticosteroids on the mortality of critically ill COVID-19 patients, isolation, loneliness and psychological distress during COVID-19, the selection of volunteers for COVID-19 vaccine trials, the mental health of children and adolescents during COVID-19, fertility preservation through hormonal intervention for transgender adolescents, safe, effective and affordable COVID-19 vaccines, essential requirements for acceptance of a COVID-19 vaccine, ischemic stroke rates from COVID-19 and influenza, mandatory COVID-19 vaccination of children, COVID-19 asymptomatic children and adults, Who Dares Wins (Qui Audet Adipiscitur), even against COVID-19, global health security index and responses to COVID-19, quality of life and dying, immunity from COVID-19, whom to trust or not to trust regarding COVID-19, the value of health care for cancer patients, previous medical research bodes well for a COVID-19 vaccine, you cannot fight COVID-19 alone, causality between hypertension and COVID-19, coffee consumption and metastatic colorectal cancer, improving statistical analysis of health policies on children and adolescents, COVID-19 does not respect anyone, politics diminishes the integrity and reputation of healthcare agencies, primary, secondary and tertiary cancers in the lung, health care should include everyone, especially for COVID-19, prioritizing access to COVID-19 vaccines, further questions about COVID-19 vaccines, estimating direct and indirect excess deaths from COVID-19, herd immunity for COVID-19, daily eyeglass wear and COVID-19 infection, using anything that prevents the spread of COVID-19, deferral of care for serious non-COVID-19 conditions, society's united fight against depression and suicide, the positive outcomes in delaying low-risk thyroid cancer treatment during COVID-19, the likely future toll from COVID-19, excluding older persons from vaccine and clinical trials for COVID-19, peaceful miracles make the moment, dealing with COVID-19 science denial and conspiracy theories, masking and testing should be mandatory for COVID-19, journal reputation is established by scientific creativity and destroyed by political interference, impact and importance of medical research on COVID-19, support for COVID-19 long haulers, possible reinfection and long term recovery from COVID-19, Wabi-Sabi and the beauty of imperfection, good, better and best testing for COVID-19, surgical technical skill and long-term cancer survival, prior negative recovery from RT-PCR test results for COVID-19, age, frailty, and postoperative surgical outcomes, all journals should have diversity in the editorial and peer review process, an encompassing digital open access journal - JAMA Health Forum, righting inequities through otolaryngology in a COVID-19 normal America, resilient mental health in older adults under COVID-19, preventing suicides in a COVID-19 normal world, and COVID-19, voluntary art cipation in cancer clinical trials, herd immunity and COVID-19, psychological distress of US adults under COVID-19, repurposing drugs for COVID-19, same data + different models = different results, how do surges in COVID-19 affect healthcare spending?, causality between sedentary behavior and cancer mortality, overdose cardiac arrests and emergency medicine during COVID-19, COVID-19 asymptomatic children versus adults, why is care for serious non-COVID-19 conditions seemingly deferred?, confidentiality in a world of COVID-19 and fake news, mental healthcare data disrupted by COVID-19, do N95 face masks protect against COVID-19?, the necessity of face masks during COVID-19, nurses in COVID-19 vaccine trials, eye protection for COVID-19 ventilated patients, and healthcare access, social needs, unemployment insurance during COVID-19, pre-eminent experts evaluate the distribution of COVID-19 vaccines, the effects of current vaccines against SARS-CoV-2 and COVID-19 mutations, unbearable suffering needs to be respected, varied public attitudes toward COVID-19 vaccine mandates, enanthems, exanthems, and COVID-19, a wish list for a COVID-19 new year, critical statistical rigour before and during COVID-19, accepting vaccines is essential against COVID-19, and social distancing, health behaviour, cancer outcomes during COVID-19, readmission and death from COVID-19 after hospital discharge, beneficial lessons from COVID-19, estimating racial disparities in COVID-19 testing, paying people to be vaccinated against COVID-19, COVID-19 mutations and vaccines, mandatory vaccinations against COVID-19, allergic reactions to the first dose of the Pfizer vaccine, neutralization of monoclonal antibodies for COVID-19, pricing teledermatology during COVID-19, and SARS-CoV-2 COVID-19 are spreading virtually everywhere, transmission of SARS-CoV-2 and COVID-19 by children, addressing racial and ethnic health disparities during COVID-19, race and medical research during and after COVID-19, adherence to nonpharmaceutical interventions during COVID-19, further unanswered questions for cancer patients during COVID-19, how are children affected by COVID-19, is the California variant another COVID-19 escaped mutant?, tracking escaped mutants of SARS-CoV-2 and COVID-19, optimal timing separation and strength of prime and booster shots, confounding errors in response to COVID-19, durability and duration of approved vaccines against escaped mutants, and hospital mortality and hospice discharge of COVID-19 patients depend on population size © 2021 Hindawi Limited All rights reserved","PeriodicalId":38875,"journal":{"name":"Advances in Decision Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Decision Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47654/v25y2021i1p40-142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Decision Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
The world community has been changed irrevocably by the highly infectious and mutating SARSCoV-2 virus that causes the COVID-19 disease The necessary research output on COVID-19 has been revolutionary, especially in the medical and biomedical sciences, where the search for a vaccine is essential for the world to have a semblance of normality in the era of COVID-19 Much of the advanced research has been distributed in the leading medical journals, including the Journal of the American Medical Association (JAMA), where the latest medical research is distributed on a daily basis, and where comments can also be published The purpose of this paper is to provide a critique of 110 interesting and highly topical research papers that have been published in JAMA, mostly within the past two months The diverse topics include: treating influenza and COVID-19 simultaneously, dealing with a second wave of COVID-19 in Beijing, honesty is best for known and unknown GAWI and WIST, unreliability of asymptomatic COVID-19 testing outcomes for children, the effectiveness of flu vaccines, acute anxiety during COVID-19, MAID as an end of life option, longer-term effects of corticosteroids on the mortality of critically ill COVID-19 patients, isolation, loneliness and psychological distress during COVID-19, the selection of volunteers for COVID-19 vaccine trials, the mental health of children and adolescents during COVID-19, fertility preservation through hormonal intervention for transgender adolescents, safe, effective and affordable COVID-19 vaccines, essential requirements for acceptance of a COVID-19 vaccine, ischemic stroke rates from COVID-19 and influenza, mandatory COVID-19 vaccination of children, COVID-19 asymptomatic children and adults, Who Dares Wins (Qui Audet Adipiscitur), even against COVID-19, global health security index and responses to COVID-19, quality of life and dying, immunity from COVID-19, whom to trust or not to trust regarding COVID-19, the value of health care for cancer patients, previous medical research bodes well for a COVID-19 vaccine, you cannot fight COVID-19 alone, causality between hypertension and COVID-19, coffee consumption and metastatic colorectal cancer, improving statistical analysis of health policies on children and adolescents, COVID-19 does not respect anyone, politics diminishes the integrity and reputation of healthcare agencies, primary, secondary and tertiary cancers in the lung, health care should include everyone, especially for COVID-19, prioritizing access to COVID-19 vaccines, further questions about COVID-19 vaccines, estimating direct and indirect excess deaths from COVID-19, herd immunity for COVID-19, daily eyeglass wear and COVID-19 infection, using anything that prevents the spread of COVID-19, deferral of care for serious non-COVID-19 conditions, society's united fight against depression and suicide, the positive outcomes in delaying low-risk thyroid cancer treatment during COVID-19, the likely future toll from COVID-19, excluding older persons from vaccine and clinical trials for COVID-19, peaceful miracles make the moment, dealing with COVID-19 science denial and conspiracy theories, masking and testing should be mandatory for COVID-19, journal reputation is established by scientific creativity and destroyed by political interference, impact and importance of medical research on COVID-19, support for COVID-19 long haulers, possible reinfection and long term recovery from COVID-19, Wabi-Sabi and the beauty of imperfection, good, better and best testing for COVID-19, surgical technical skill and long-term cancer survival, prior negative recovery from RT-PCR test results for COVID-19, age, frailty, and postoperative surgical outcomes, all journals should have diversity in the editorial and peer review process, an encompassing digital open access journal - JAMA Health Forum, righting inequities through otolaryngology in a COVID-19 normal America, resilient mental health in older adults under COVID-19, preventing suicides in a COVID-19 normal world, and COVID-19, voluntary art cipation in cancer clinical trials, herd immunity and COVID-19, psychological distress of US adults under COVID-19, repurposing drugs for COVID-19, same data + different models = different results, how do surges in COVID-19 affect healthcare spending?, causality between sedentary behavior and cancer mortality, overdose cardiac arrests and emergency medicine during COVID-19, COVID-19 asymptomatic children versus adults, why is care for serious non-COVID-19 conditions seemingly deferred?, confidentiality in a world of COVID-19 and fake news, mental healthcare data disrupted by COVID-19, do N95 face masks protect against COVID-19?, the necessity of face masks during COVID-19, nurses in COVID-19 vaccine trials, eye protection for COVID-19 ventilated patients, and healthcare access, social needs, unemployment insurance during COVID-19, pre-eminent experts evaluate the distribution of COVID-19 vaccines, the effects of current vaccines against SARS-CoV-2 and COVID-19 mutations, unbearable suffering needs to be respected, varied public attitudes toward COVID-19 vaccine mandates, enanthems, exanthems, and COVID-19, a wish list for a COVID-19 new year, critical statistical rigour before and during COVID-19, accepting vaccines is essential against COVID-19, and social distancing, health behaviour, cancer outcomes during COVID-19, readmission and death from COVID-19 after hospital discharge, beneficial lessons from COVID-19, estimating racial disparities in COVID-19 testing, paying people to be vaccinated against COVID-19, COVID-19 mutations and vaccines, mandatory vaccinations against COVID-19, allergic reactions to the first dose of the Pfizer vaccine, neutralization of monoclonal antibodies for COVID-19, pricing teledermatology during COVID-19, and SARS-CoV-2 COVID-19 are spreading virtually everywhere, transmission of SARS-CoV-2 and COVID-19 by children, addressing racial and ethnic health disparities during COVID-19, race and medical research during and after COVID-19, adherence to nonpharmaceutical interventions during COVID-19, further unanswered questions for cancer patients during COVID-19, how are children affected by COVID-19, is the California variant another COVID-19 escaped mutant?, tracking escaped mutants of SARS-CoV-2 and COVID-19, optimal timing separation and strength of prime and booster shots, confounding errors in response to COVID-19, durability and duration of approved vaccines against escaped mutants, and hospital mortality and hospice discharge of COVID-19 patients depend on population size © 2021 Hindawi Limited All rights reserved
《美国医学会杂志》近期关于COVID-19的医学研究评论
关于COVID-19的必要研究成果是革命性的,特别是在医学和生物医学科学领域,寻找疫苗对于使世界在COVID-19时代恢复正常至关重要。许多先进研究成果已发表在主要医学期刊上。包括《美国医学协会杂志》(JAMA),每天都会发布最新的医学研究,也可以发表评论。本文的目的是对JAMA上发表的110篇有趣且高度热门的研究论文进行评论,这些论文大多是在过去两个月内发表的。同时治疗流感和COVID-19,应对北京的第二波COVID-19,对于已知和未知的GAWI和WIST来说,诚实是最好的,对儿童无症状COVID-19检测结果的不可靠性,流感疫苗的有效性,COVID-19期间的急性焦虑,MAID作为生命终结选择,皮质类固醇对COVID-19危重患者死亡率的长期影响,COVID-19期间的隔离,孤独和心理困扰,COVID-19疫苗试验志愿者的选择、COVID-19期间儿童和青少年的心理健康、跨性别青少年通过激素干预保持生育能力、安全、有效和负担得起的COVID-19疫苗、接受COVID-19疫苗的基本要求、COVID-19和流感的缺血性卒中发生率、儿童强制接种COVID-19疫苗、COVID-19无症状儿童和成人、谁敢赢(Qui Audet Adipiscitur)、即使是针对COVID-19,全球卫生安全指数和对COVID-19的反应,生活质量和死亡,COVID-19的免疫力,关于COVID-19的信任或不信任谁,癌症患者的医疗保健价值,先前的医学研究预示着COVID-19疫苗的良好前景,你不能单独对抗COVID-19,高血压和COVID-19之间的因果关系,咖啡消费和转移性结直肠癌,改进儿童和青少年卫生政策的统计分析,COVID-19不尊重任何人,政治削弱了医疗机构的诚信和声誉,原发性、继发性和三级肺癌,医疗保健应包括所有人,特别是针对COVID-19,优先获得COVID-19疫苗,进一步询问COVID-19疫苗,估计COVID-19直接和间接的额外死亡人数,COVID-19的群体免疫力,日常佩戴眼镜和COVID-19感染,使用任何防止COVID-19传播的方法,对严重非COVID-19疾病的延迟护理,社会团结起来打击抑郁和自杀,COVID-19期间延迟低风险甲状腺癌治疗的积极成果,COVID-19未来可能造成的死亡,将老年人排除在COVID-19疫苗和临床试验之外,和平奇迹创造时刻,应对COVID-19科学否认和阴谋论,对COVID-19进行强制性掩盖和检测,期刊的声誉是由科学创造力建立起来的,却被政治干预、医学研究对COVID-19的影响和重要性、对COVID-19长途携带者的支持、可能的再感染和COVID-19的长期恢复、Wabi-Sabi和不完美之美、COVID-19的良好、更好和最佳检测、手术技术技能和长期癌症生存、COVID-19 RT-PCR检测结果的既往阴性恢复、年龄、虚弱、所有期刊在编辑和同行评审过程中都应该具有多样性,一个全面的数字开放获取期刊- JAMA健康论坛,在COVID-19正常的美国通过耳鼻喉科纠正不公平现象,COVID-19下老年人的弹性心理健康,在COVID-19正常的世界预防自杀,COVID-19,自愿参与癌症临床试验,群体免疫和COVID-19, COVID-19下美国成年人的心理困扰,针对COVID-19重新使用药物,相同的数据+不同的模型=不同的结果,COVID-19的激增如何影响医疗支出?久坐行为与癌症死亡率之间的因果关系、COVID-19期间心脏骤停过量和急诊用药、COVID-19无症状儿童与成人的对比,为什么对严重非COVID-19疾病的治疗似乎被推迟了?在COVID-19和假新闻的世界中保密,被COVID-19破坏的精神卫生保健数据,N95口罩能预防COVID-19吗? 2019冠状病毒病期间戴口罩的必要性,COVID-19疫苗试验中的护士,COVID-19通气患者的眼睛保护,以及COVID-19期间的医疗保健,社会需求,失业保险,知名专家评估COVID-19疫苗的分布,现有疫苗对SARS-CoV-2和COVID-19突变的影响,难以忍受的痛苦需要得到尊重,公众对COVID-19疫苗授权,enenth, exanth和COVID-19的不同态度,2019冠状病毒病新年愿望清单、2019冠状病毒病之前和期间的关键统计严谨性、接受疫苗对预防2019冠状病毒病至关重要、保持社交距离、健康行为、2019冠状病毒病期间的癌症结局、出院后的再入院和死亡、从2019冠状病毒病中获得的有益经验、估计COVID-19检测中的种族差异、付费接种疫苗、COVID-19突变和疫苗、强制接种COVID-19疫苗、第一剂辉瑞疫苗的过敏反应、COVID-19单克隆抗体的中和作用、COVID-19和SARS-CoV-2期间的远程皮肤病定价、SARS-CoV-2和COVID-19在儿童中的传播、解决COVID-19期间的种族和民族健康差异、COVID-19期间和之后的种族和医学研究、COVID-19期间坚持非药物干预措施、在COVID-19期间,癌症患者面临的进一步悬而未决的问题是,儿童如何受到COVID-19的影响,加州变体是否是另一种COVID-19逃逸突变体?、追踪SARS-CoV-2和COVID-19逃逸突变体、初始和加强疫苗的最佳分离时间和强度、应对COVID-19的混淆错误、针对逃逸突变体的批准疫苗的持久性和持续时间,以及COVID-19患者的住院死亡率和临终关怀出院取决于人口规模©2021 Hindawi Limited所有权利保留
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