Diagnosis of Chronic Kidney Disease in the Elderly – A Challenge for the Practitioner

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Romanian Journal of Military Medicine Pub Date : 2023-01-01 DOI:10.55453/rjmm.2023.126.2.15
D. Radulescu, F. Perde, C. David, G. Lupusoru, M. Lupușoru, F. Tulin, D. Ionescu, A. Călinoiu, Sebastian Isac, I. A. Vacaroiu
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Abstract

"The recent increase in life expectancy is the main argument for a better understanding of the pathophysiological mechanisms underlying aging. These, once known, can provide possible links to therapies to prevent aging or slow down the process. Normal aging is associated with a progressive decrease in the glomerular filtration rate. Accurate estimation of GFR in the elderly is under the suspicion of multiple errors mainly due to sarcopenia and decreased protein intake. Differentiation between chronic kidney disease and the physiological decline of GFR might be a challenge in clinical practice and this has consequences on the evolution and treatment of the numerous comorbidities of the elderly. The current trend to use non-invasive diagnostic techniques explains the need to identify a serological marker to help differentiate between decreased GFR secondary to kidney aging or the development of chronic kidney disease."
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老年慢性肾病的诊断——对医生的挑战
“最近预期寿命的增加是更好地理解衰老背后的病理生理机制的主要论据。一旦知道了这些,就可以为预防衰老或减缓衰老过程的治疗提供可能的联系。正常的衰老与肾小球滤过率的逐渐降低有关。老年人GFR的准确估计存在多重误差,主要是由于肌肉减少和蛋白质摄入减少。鉴别慢性肾脏疾病和生理性GFR下降在临床实践中可能是一个挑战,这对老年人众多合并症的发展和治疗产生了影响。目前使用非侵入性诊断技术的趋势解释了需要确定一种血清学标记物来帮助区分继发于肾脏衰老的GFR下降或慢性肾脏疾病的发展。”
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
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