C. Kosmidis, G. Koimtzis, G. Pantos, S. Atmatzidis, E. Pavlidis, M. Kosmidou, C. Efthimiadis, G. Anthimidis, N. Varsamis, Eleni Georgakoudi, A. Tsakalidis, I. Koskinas, A. Paraschou, Konstantina Tsopouridou, Nikos Tteralli, T. Koletsa, Katerina Zarampouka, Isaac I. Kesisoglou, K. Sapalidis, P. Zarogoulidis
{"title":"Gene Therapy for Hepatocellular Carcinoma: An Update","authors":"C. Kosmidis, G. Koimtzis, G. Pantos, S. Atmatzidis, E. Pavlidis, M. Kosmidou, C. Efthimiadis, G. Anthimidis, N. Varsamis, Eleni Georgakoudi, A. Tsakalidis, I. Koskinas, A. Paraschou, Konstantina Tsopouridou, Nikos Tteralli, T. Koletsa, Katerina Zarampouka, Isaac I. Kesisoglou, K. Sapalidis, P. Zarogoulidis","doi":"10.7150/jbm.29161","DOIUrl":null,"url":null,"abstract":"Current statistics indicate that hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related death. Major predisposing conditions are hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. To date treatment approach includes liver transplantation, surgical resection and or ablation, however; recurrence, metastasis, and mortality still remains high. Therefore, alternative treatments such as gene therapy is increasingly being considered as a feasible proposal. In this mini review we will focus on novel data of the past 10 years on the subject of gene therapy and hepatocellular carcinoma.","PeriodicalId":91898,"journal":{"name":"Journal of Biomedicine (Sydney, NSW)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomedicine (Sydney, NSW)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7150/jbm.29161","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Current statistics indicate that hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related death. Major predisposing conditions are hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. To date treatment approach includes liver transplantation, surgical resection and or ablation, however; recurrence, metastasis, and mortality still remains high. Therefore, alternative treatments such as gene therapy is increasingly being considered as a feasible proposal. In this mini review we will focus on novel data of the past 10 years on the subject of gene therapy and hepatocellular carcinoma.