Sustained virological response after only 5 weeks treatment with daclatasvir/pegylated interferon and ribavirin as part of a clinical trial in a cirrhotic human immunodeficiency virus (HIV) - hepatitis C virus (HCV) co-infected patient with liver decompensation during treatment

Abstract

A 57 year old white British bisexual man was referred to the Hepatology department for investigation of raised alanine aminotransferase (ALT) and raised gammaglutamyl transferase (GGT) discovered on a routine health screen. He was known to have essential hypertension, diet-controlled type 2 diabetes mellitus, gout and vitamin d deficiency. His alcohol intake had always been minimal at less than 8 units per month, and there was no history of intravenous drug use. Losartan 50 mg was prescribed to him once daily by his general practitioner (GP), and he did not use over the counter preparations or herbal medications. Further investigations revealed the patient to be