CCL2/MCP-1 serum chemokine level in patients with odontogenic infectious and inflammatory diseases of the soft tissues of the maxillofacial area and mediastinum

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Acta Facultatis Medicae Naissensis Pub Date : 2022-01-01 DOI:10.5937/afmnai39-34181

M. Faustova, O. Nazarchuk, D. Dmytriiev, D. Avetikov, G. Loban', Y. Babina, M. Ananieva

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Abstract

Aim. The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum. Methods. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients' plasma CCL2/MCP-1 level was determined using a kit for specific ELISA. Results. The findings of the studies showed a statistically significant increase in the concentration of plasma CCL2/MCP-1 in patients of all study groups. Our study shows a significant increase in plasma CCL2/MCP-1 level in patients with odontogenic phlegmonas, abscesses and mediastinitis, compared to the group of healthy subjects. Conclusion. CCL2/MCP-1 may play an important role in the pathogenesis of odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum, which requires a careful follow-up study.

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颌面部和纵隔软组织感染性和炎症性疾病患者血清CCL2/MCP-1趋化因子水平的研究

的目标。本研究旨在检测颌面部和纵隔软组织感染性和炎症性疾病患者的CCL2/MCP-1水平。方法。研究对象为46例颌面部软组织感染性炎症性疾病患者和12名健康志愿者。采用特异性ELISA试剂盒检测患者血浆CCL2/MCP-1水平。结果。研究结果显示，所有研究组患者血浆CCL2/MCP-1浓度均有统计学显著升高。我们的研究显示，与健康人群相比，牙源性痰、脓肿和纵隔炎患者血浆CCL2/MCP-1水平显著升高。结论。CCL2/MCP-1可能在颌面及纵隔软组织的牙源性感染性和炎症性疾病的发病机制中发挥重要作用，需要仔细的随访研究。

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