In vitro antimicrobial activity of different Verbascum niveum extracts

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Acta Facultatis Medicae Naissensis Pub Date : 2023-01-01 DOI:10.5937/afmnai40-40582
Maja Grigorov, D. Pavlović, S. Mladenović-Antić, M. Tasić-Kostov, Dusan S Ilic
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Abstract

Introduction. Medicinal plants are the main ingredient of numerous medicines and pharmaceutical products, and antimicrobial activity has been demonstrated in a large number of medicinal plant extracts and essential oils. Considering that Verbascum L. species (mullein), officially approved by the European Medicines Agency, show antimicrobial properties, but also that there are species of this genus that have not been sufficiently studied, the aim of this study was to evaluate the antimicrobial activity of six different extracts of Verbascum niveum Ten. Material and methods. Antimicrobial bioassays were performed with one fungus (Candida albicans) and four bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis) by broth microdilution method according to the recommendations of the European Committee on Antimicrobial Susceptibility Testing. The results were expressed as the minimal inhibitory concentration (MIC) of an extract (mg/ml) that prevents the visible growth of bacteria/fungi. Results. The MIC values ranged from 0.39 to 1.25 mg/ml. The strongest effect was obtained with the ethanolic extract of leaves against Staphylococcus aureus (0.39 mg/ml). Conclusion. Although Verbascum species are considered to be an excellent antimicrobial agent, according to our result, the tested extracts had modest antimicrobial activity.
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不同荆芥提取物的体外抑菌活性研究
介绍。药用植物是许多药物和医药产品的主要成分,大量药用植物提取物和精油已被证明具有抗菌活性。考虑到欧洲药品管理局(European Medicines Agency)正式批准的毛蕊花属(Verbascum L.)具有抗菌特性,但也有该属的物种尚未得到充分的研究,本研究的目的是评估毛蕊花六种不同提取物的抗菌活性。材料和方法。采用微量肉汤稀释法对1株真菌(白色念珠菌)和4株细菌(大肠埃希菌、铜绿假单胞菌、金黄色葡萄球菌、粪肠球菌)进行抗菌生物试验,试验方法参照欧洲药敏试验委员会的建议。结果表示为提取物的最小抑制浓度(MIC) (mg/ml),可以阻止细菌/真菌的可见生长。结果。MIC值为0.39 ~ 1.25 mg/ml。叶乙醇提取物对金黄色葡萄球菌的抑制作用最强(0.39 mg/ml)。结论。虽然verbasum被认为是一种很好的抗菌剂,但根据我们的结果,所测试的提取物具有适度的抗菌活性。
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来源期刊
Acta Facultatis Medicae Naissensis
Acta Facultatis Medicae Naissensis MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
0.00%
发文量
13
审稿时长
12 weeks
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