Effect of Lipid Levels on Tumor-Infiltrating Lymphocytes and Prognosis in Patients with Triple-Negative Breast Cancer.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY Breast Care Pub Date : 2023-10-01 Epub Date: 2023-08-29 DOI:10.1159/000531943

NiJiati AiErken, Nan Shao, Yuhong Liu, Huijuan Shi, Yawei Shi, Zhongyu Yuan, Ying Lin

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Abstract

Objective: Dyslipidemia can promote cell proliferation, malignant transformation, metastasis, and cancer recurrence. Moreover, it could also affect immune infiltration in the tumor microenvironment. Therefore, we aimed to explore the effects of lipid levels on tumor-infiltrating lymphocytes (TILs) and prognosis in patients with triple-negative breast cancer (TNBC).

Methods: Samples from 222 patients with TNBC from July 2007 to December 2019 were obtained from the tissue specimen banks in 3 hospitals. The blood samples were used to detect the levels of lipid levels such as apolipoprotein B (Apo B), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C). The TILs in the 222 TNBC tissues were detected using hematoxylin and eosin (H&E) staining, and the relationship between the lipid levels, clinical characteristics, and prognosis was analyzed.

Results: Among TNBC patients, the overall survival (OS) time and disease-free survival (DFS) time were lower in patients with high LDL-C levels than those with low LDL-C levels (p < 0.01, respectively). The DFS was shorter in patients with low stromal TIL (STIL) levels than those with moderate or high STIL levels (p = 0.023). Multifactor Cox regression analysis showed that LDL-C level, Apo B level, and lymphocyte-predominant breast cancer were independent risk factors for OS in TNBC patients. The number of positive lymph nodes, postoperative staging, and total amount of TILs were independent risk factors for DFS in TNBC patients.

Conclusion: The LDL-C and STIL levels were correlated with survival and prognosis in patients with TNBC.

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脂质水平对癌症三阴性乳腺癌患者肿瘤浸润淋巴细胞和预后的影响。

目的：血脂异常可促进细胞增殖、恶性转化、转移和癌症复发。此外，它还可能影响肿瘤微环境中的免疫浸润。因此，我们旨在探讨脂质水平对癌症三阴性患者肿瘤浸润性淋巴细胞（TIL）和预后的影响。血液样本用于检测脂质水平，如载脂蛋白B（Apo B）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）。使用苏木精和伊红（H&E）染色检测222例TNBC组织中的TIL，并分析脂质水平、临床特征和预后之间的关系。结果：在TNBC患者中，高LDL-C患者的总生存期（OS）和无病生存期（DFS）低于低LDL-C的患者（分别p<0.01）。低基质TIL（STIL）水平的患者的DFS比中、高STIL水平的患者更短（p=0.023）。多因素Cox回归分析表明，LDL-C水平、Apo B水平和淋巴细胞优先的乳腺癌症是TNBC患者OS的独立危险因素。阳性淋巴结数量、术后分期和TIL总量是TNBC患者DFS的独立危险因素。结论：低密度脂蛋白胆固醇和STIL水平与TNBC患者的生存和预后有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Care 医学-妇产科学

CiteScore

4.40

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Breast Care'' is a peer-reviewed scientific journal that covers all aspects of breast biology. Due to its interdisciplinary perspective, it encompasses articles on basic research, prevention, diagnosis, and treatment of malignant diseases of the breast. In addition to presenting current developments in clinical research, the scope of clinical practice is broadened by including articles on relevant legal, financial and economic issues.