Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders.

Q3 Medicine Current aging science Pub Date : 2024-01-01 DOI:10.2174/1874609816666230816090934

Inês Marques-Aleixo, Arnaldina Sampaio, Lucimére Bohn, Flavia Machado, Duarte Barros, Oscár Ribeiro, Joana Carvalho, José Magalhães

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Abstract

Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD).

Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS.

Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diagnosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer's Disease scale) were evaluated, and blood samples were collected for biochemical analysis.

Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic zscore (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength.

Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.

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神经精神症状与主要神经认知障碍的血液生物标志物有关。

背景：神经精神症状（NPS）在患有严重神经认知障碍（MNCD）的个体中非常普遍。目的：根据NPS，我们对MNCD患者的血液生物标志物（代谢、炎症、神经营养特征和总抗氧化剂）、身体成分、身体素质和生活质量（QoL）进行了表征。方法：样本包括34名老年人（71.4%为女性；74.06±6.03岁，诊断为MNCD），根据NPS（神经精神问卷）的第50百分位[低（≤12）或高（≥13）]进行分类。评估社会形态、临床数据、身体成分、人体测量、认知评估（ADAS-Cog）、体能（老年人体能测试）、生活质量（生活质量阿尔茨海默病量表），并采集血样进行生化分析。结果：与高NPS组相比，低NPS组显示出更高水平的IL-6、IGF-1和神经营养核心（IGF-1、VEGF-1、BDNF的复合物）。此外，与高NPS组相比，低NPS组具有更高的生活质量、有氧健身以及上半身和下半身力量。结论：NPS的严重程度似乎与改良的神经营养和炎症结果、较低的身体素质和较差的生活质量有关。对抗NPS发展的策略可以保护MNCD患者的身心健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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