T lymphocytes-related cell network in the pathogenesis of juvenile idiopathic arthritis: a key point for personalized treatment.

IF 5.2 2区医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2024-01-01 Epub Date: 2023-10-27 DOI:10.1097/BOR.0000000000000991

Alessio Mazzoni, Francesco Annunziato, Laura Maggi

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Abstract

Purpose of review: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritis of unknown origin occurring in children under 16 years of age and persisting for at least 6 weeks. Given that JIA is an inflammatory disorder, treatment strategies, including also biologicals, are focused on suppressing excessive inflammation. The finding that different patients display different responses to biological drugs supports the concept that different pathogenic mechanisms can exist in JIA, with specific cellular and molecular mechanisms driving inflammation in each patient. The aim of this review is to highlight the most recent advances in understanding the role of immune cells in JIA pathogenesis.

Recent findings: This review encompasses the role of the different cell subsets involved in sustaining inflammation in JIA, with a particular emphasis on T cells, as they orchestrate both innate and adaptive auto-reactive immunity in affected joints.

Summary: The characterization of the cellular and molecular pathways supporting inflammation will be crucial to design novel therapeutic approaches in the context of personalized medicine.

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T淋巴细胞相关细胞网络在幼年特发性关节炎发病机制中的作用：个性化治疗的关键。

综述目的：青少年特发性关节炎（JIA）是一组起源不明的异质性关节炎，发生在16岁以下儿童中年，并持续至少6年周。鉴于JIA是一种炎症性疾病，治疗策略，包括生物制剂，都集中在抑制过度炎症上。不同的患者对生物药物表现出不同的反应，这一发现支持了JIA可能存在不同的致病机制的概念，每个患者都有特定的细胞和分子机制驱动炎症。这篇综述的目的是强调在理解免疫细胞在JIA发病机制中的作用方面的最新进展。最近的发现：这篇综述涵盖了参与维持JIA炎症的不同细胞亚群的作用，特别强调了T细胞，因为它们在受影响的关节中协调先天和适应性自身反应免疫。摘要：支持炎症的细胞和分子途径的表征对于在个性化医学的背景下设计新的治疗方法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in rheumatology 医学-风湿病学

CiteScore

9.70

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.