The effect of crocin-selenium nanoparticles on the cognition and oxidative stress markers of multiple sclerosis patients: a randomized triple-blinded placebo-controlled clinical trial

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2023-11-02 DOI:10.1007/s10534-023-00548-z
Nasim Rezaeimanesh, Pegah Rafiee, Roghayyeh Saeedi, Pegah Khosravian, Mohammad Ali Sahraian, Sharareh Eskandarieh, Abdorreza Naser Moghadasi, Soodeh Razeghi Jahromi
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Abstract

The prevalence of cognitive impairment in multiple sclerosis (MS) patients is estimated to be approximately 40–60%. There is an increasing body of evidence regarding the impact of both selenium and crocin as antioxidant agents on cognitive function. In the present study, for the first time, we investigated the effect of crocin-selenium nanoparticles (Cor@SeNs) on cognitive function and oxidative stress markers in MS patients. A triple-blind randomized clinical trial was conducted among 60 MS patients. The participants were randomly divided in a 1:1 ratio to either the Cor@SeNs or placebo group, employing block randomization. During the course of 12 weeks, the participants received Cor@SeNs capsules, containing 5.74 mg crocin and 55 mcg Selenium, or placebo capsules. Cognition assessed using the Persian version of the Brief International Cognitive Assessment for MS (BICAMS) battery. Serum levels of total antioxidant capacity (TAC), glutathione reductase (GR) activity and malondialdehyde (MDA) determined by colorimetric kits. Data analysis was performed in SPSS, version 26. P < 0.05 was considered as the significant range. The mean ± SD of TAC change was 0.03 ± 0.07 mM vs. − 0.03 ± 0.09 mM in intervention and placebo groups, respectively (Time × group effect P: 0.01; effect size: 0.10). The time effect of intervention on the California Verbal Learning Test second edition (CVLT-II) (P < 0.01; effect size: 0.29), CVLT-II-delay (P < 0.01; effect size: 0.29), and the Symbol Digit Modalities Test (SDMT) (P < 0.01; effect size: 0.18) was increasing and significant. In addition, the time effect of intervention on GR activity was significant and decreasing in both groups (P < 0.01; effect size: 0.20). Our results suggested a significant effect of the Cor@SeNs intervention in improving TAC. We also observed a significant improvement in cognitive function in both groups during our study. However, although not statistically significant, a higher amount of change in cognitive function and serum antioxidant markers was noted in the Cor@SeNs group compared to the placebo group. This is the first study on this nano product with low dose of selenium and crocin. More investigations with longer duration and varied doses are suggested.

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番红花硒纳米颗粒对多发性硬化症患者认知和氧化应激标志物的影响:一项随机三盲安慰剂对照临床试验。
多发性硬化症(MS)患者认知障碍的患病率估计约为40-60%。越来越多的证据表明硒和番红花苷作为抗氧化剂对认知功能的影响。在本研究中,我们首次研究了番红花素硒纳米颗粒的作用(Cor@SeNs)多发性硬化症患者的认知功能和氧化应激标志物。在60名MS患者中进行了一项三盲随机临床试验。参与者以1:1的比例被随机分为Cor@SeNs或安慰剂组,采用分组随机化。在12周的过程中,参与者收到Cor@SeNs胶囊,含有5.74 mg番红花苷和55 mcg硒,或安慰剂胶囊。认知评估使用波斯语版的MS国际认知评估(BIAMS)电池。用比色试剂盒测定血清总抗氧化能力(TAC)、谷胱甘肽还原酶(GR)活性和丙二醛(MDA)水平。数据分析采用SPSS第26版软件进行。P
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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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