Menopausal age and cardiovascular disease risk in American women: evidence from the National Health and Nutrition Examination Survey.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY Climacteric Pub Date : 2024-04-01 Epub Date: 2023-11-03 DOI:10.1080/13697137.2023.2273526

Z Zhang, Y Hu, X Cui, M Lu, M Zhang, C Li

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Abstract

Objective: Cardiovascular disease (CVD) is a significant contributor to the deaths of females, and premature menopause adds to the risk of CVD in females. Therefore, our study aimed to investigate the age of menopause and CVD incidence in American females using data from the National Health and Nutrition Examination Survey (NHANES).

Method: We analyzed data from 6347 females to investigate the association between menopausal age and the risk of CVD using multivariate logistic regression analysis.

Results: The study found that a later menopausal age reduces the risk of developing CVD (odds ratio [OR] = 0.74, 95% confidence interval [CI] = 0.63 - 0.88, p < 0.001). Moreover, females with early-onset CVD had an increased risk of premature menopause before the age of 40 years (OR = 2.44, 95% CI = 1.60 - 3.72, p < 0.001).

Conclusion: Menopausal age is associated with the risk of developing CVD in American females. Specifically, if menopause occurs earlier, there is an increased risk of CVD. Additionally, early-onset CVD significantly raises the risk of premature menopause, which in turn has important implications for female reproductive health.

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美国妇女的更年期年龄和心血管疾病风险：来自国家健康和营养检查调查的证据。

目的：心血管疾病（CVD）是女性死亡的重要原因，过早绝经增加了女性心血管疾病的风险。因此，我们的研究旨在利用美国国家健康和营养检查调查（NHANES）的数据来调查美国女性的更年期年龄和心血管疾病的发病率。方法：我们分析了6347名女性的数据，使用多变量逻辑回归分析来调查更年期年龄与心血管疾病风险之间的关系。结果：研究发现，绝经年龄越晚，患心血管疾病的风险就越低（比值比[OR] = 0.74，95%置信区间[CI] = 0.63 - 0.88，p p 结论：美国女性的更年期年龄与患心血管疾病的风险相关。具体来说，如果更年期提前，患心血管疾病的风险就会增加。此外，早发性心血管疾病显著增加了过早绝经的风险，这反过来又对女性生殖健康产生了重要影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.