Toxicity of superparamagnetic iron oxide nanoparticles on retinoblastoma mitochondria.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-03-01 Epub Date: 2023-10-31 DOI:10.1080/15569527.2023.2275030

Enayatollah Seydi, Ghazaleh Tahmasebi, Abdollah Arjmand, Jalal Pourahmad

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Abstract

Purpose: Retinoblastoma (RB) is one of the most important cancers in children with a higher rate of prevalence in developing countries. Despite different approaches to the treatment of RB, it seems necessary to discover a new approach to its treatment. Today, mitochondria are recognised as an important target in the treatment of cancer. Superparamagnetic iron oxide nanoparticles (SPIONs) have been studied by researchers due to their important biological effects.

Methods: In this study, the effects of SPIONs on mitochondria isolated from Y79 retinoblastoma cells were investigated.

Results: The results showed that SPIONs were able to increase the reactive oxygen species (ROS) level and subsequently damage the mitochondrial membrane and release cytochrome c a as one of the important pro-apoptotic proteins of RB mitochondria. Furthermore, the results indicated a decrease in cell viability and an increase in caspase-3 activity in Y79 retinoblastoma cells.

Conclusions: These events can lead to the killing of cancerous mitochondria. Our results suggest that SPIONs can cause mitochondrial dysfunction and death in RB mitochondria.

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超顺磁性氧化铁纳米粒子对视网膜母细胞瘤线粒体的毒性。

目的：视网膜母细胞瘤（RB）是儿童最重要的癌症之一，在发展中国家发病率较高。尽管RB的治疗方法不同，但似乎有必要发现一种新的治疗方法。如今，线粒体被认为是治疗癌症的重要靶点。超顺磁性氧化铁纳米粒子（SPION）由于其重要的生物学效应而被研究人员研究。方法：研究SPION对Y79视网膜母细胞瘤细胞线粒体的影响。结果：SPIONs能够增加活性氧（ROS）水平，进而破坏线粒体膜，并释放细胞色素c a作为RB线粒体的重要促凋亡蛋白之一。此外，结果表明Y79视网膜母细胞瘤细胞的细胞活力降低，胱天蛋白酶-3活性增加。结论：这些事件可导致癌性线粒体的死亡。我们的研究结果表明，SPION可导致RB线粒体功能障碍和死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cutaneous and Ocular Toxicology 医学-毒理学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.