The Potential Role of Persister Cells in Urinary Tract Infections.

IF 2.5 2区 医学 Q2 UROLOGY & NEPHROLOGY Current Urology Reports Pub Date : 2023-11-01 DOI:10.1007/s11934-023-01182-5
Butool Durrani, Ashu Mohammad, Bernardita M Ljubetic, Amy D Dobberfuhl
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Abstract

Purpose of review: This review explores the role of persister cells in urinary tract infections (UTIs). UTIs are one of the most common bacterial infections, affecting millions of people worldwide. Persister cells are a subpopulation of bacteria with dormant metabolic activity which allows survival in the presence of antibiotics.

Recent findings: This review summarizes recent research on the pathogenesis of persister cell formation in UTIs, the impact of persister cells on the effectiveness of antibiotics, the challenges they pose for treatment, and the need for new strategies to target these cells. Furthermore, this review examines the current state of research on the identification and characterization of persister cells in UTIs, as well as the future directions for investigations in this field. This review highlights the importance of understanding the role of persister cells in UTIs and the potential impact of targeting these cells in the development of new treatments.

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持久细胞在尿路感染中的潜在作用。
综述目的:本综述探讨了持久性细胞在尿路感染(UTIs)中的作用。尿路感染是最常见的细菌感染之一,影响着全世界数百万人。持久细胞是一种具有休眠代谢活性的细菌亚群,可以在抗生素存在下生存。最近的发现:这篇综述总结了最近关于尿路感染中持久性细胞形成的发病机制、持久性细胞对抗生素有效性的影响、它们对治疗带来的挑战以及靶向这些细胞的新策略的必要性的研究。此外,这篇综述考察了UTI中持久性细胞的鉴定和表征的研究现状,以及该领域未来的研究方向。这篇综述强调了了解持久性细胞在尿路感染中的作用的重要性,以及靶向这些细胞在开发新的治疗方法中的潜在影响。
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来源期刊
Current Urology Reports
Current Urology Reports UROLOGY & NEPHROLOGY-
CiteScore
4.60
自引率
3.80%
发文量
39
期刊介绍: This journal intends to review the most important, recently published findings in the field of urology. By providing clear, insightful, balanced contributions by international experts, the journal elucidates current and emerging approaches to the care and prevention of urologic diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as benign prostatic hyperplasia, erectile dysfunction, female urology, and kidney disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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