Aggressive periodontitis in southwestern American Indian adolescents

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of periodontology Pub Date : 2023-11-01 DOI:10.1002/JPER.23-0410
Thomas E. Rams, Adolfo Contreras, Jørgen Slots
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Abstract

Background

This study determined the prevalence of aggressive (molar-incisor pattern) (Ag/MI) periodontitis and assessed the associated subgingival bacterial-herpesvirus microbiota in Pueblo Indian adolescents in the southwestern United States.

Methods

The study included 240 Pueblo Indian adolescents, aged 13–20 years old, residing in three Rio Grande River villages in New Mexico and the Hopi Pueblo reservation in Arizona. Adolescents with Ag/MI periodontitis or periodontal health provided subgingival samples for culture of bacterial pathogens and for polymerase chain reaction detection of periodontal herpesviruses.

Results

Ag/MI periodontitis was detected in 22 (9.2%) Pueblo Indian adolescents, with 21 exhibiting a localized molar-incisor breakdown pattern. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and other red/orange complex bacterial pathogens predominated in Ag/MI periodontitis, whereas periodontal health yielded mainly viridans streptococci and Actinomyces species. Periodontal herpesviruses demonstrated a 3.5 odds ratio relationship with Ag/MI periodontitis. The only adolescent with generalized Ag/MI periodontitis harbored viral co-infection by cytomegalovirus plus Epstein–Barr virus Type 1, in addition to A. actinomycetemcomitans, P. gingivalis, and several other periodontopathic bacteria.

Conclusions

Pueblo Indian adolescents showed an unusually high prevalence of early-age Ag/MI periodontitis predominated by periodontopathic bacteria and herpesviruses suspected to be major etiologic agents of the disease.

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美国西南部印度青少年的侵袭性牙周炎。
背景:本研究确定了美国西南部普韦布洛印第安人青少年侵袭性(臼齿-切牙型)(Ag/MI)牙周炎的患病率,并评估了相关的龈下细菌疱疹病毒微生物群,居住在新墨西哥州的三个格兰德河村庄和亚利桑那州的霍皮普韦布洛保留地。患有Ag/MI牙周炎或牙周健康的青少年提供了龈下样本,用于细菌病原体的培养和牙周疱疹病毒的聚合酶链式反应检测。结果:在22名(9.2%)普韦布洛印第安人青少年中检测到Ag/MI牙周炎,其中21人表现出局部磨牙-门牙破坏模式。Ag/MI牙周炎主要由聚合放线菌、牙龈卟啉单胞菌和其他红色/橙色复合细菌病原体引起,而牙周健康主要由绿色链球菌和放线菌引起。牙周疱疹病毒与Ag/MI牙周炎的比值比为3.5。唯一一名患有全身性Ag/MI牙周炎的青少年携带巨细胞病毒加1型EB病毒,以及共放线菌、牙龈卟啉单胞菌和其他几种牙周病细菌的病毒共同感染。结论:普韦布洛-印度青少年早期Ag/MI牙周炎的患病率异常高,主要由牙周病细菌和疱疹病毒引起,怀疑它们是该疾病的主要病因。
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
期刊最新文献
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