{"title":"A new coumarin glucoside from Angelica pubescens","authors":"Han-tao Zhao , Jun Yang , Qian-feng Chen","doi":"10.1080/14786419.2023.2275265","DOIUrl":null,"url":null,"abstract":"<div><div>A new coumarin glucoside named angelol A-3'-<em>β</em>-D-glucoside and four known compounds (<strong>2–5</strong>) were isolated from the root of <em>Angelica pubescens</em>. Their chemical structures were elucidated by extensive spectroscopic methods involving HR-ESI-MS, 1D and 2D NMR. The absolute configuration of compound <strong>1</strong> was confirmed by the CD experiment. All compounds were tested for nitric oxide (NO) inhibitory activity <em>in vitro</em>. The results showed that all compounds exhibited weak to moderate inhibition activities of NO production except compound <strong>5</strong>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 526-530"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923022519","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A new coumarin glucoside named angelol A-3'-β-D-glucoside and four known compounds (2–5) were isolated from the root of Angelica pubescens. Their chemical structures were elucidated by extensive spectroscopic methods involving HR-ESI-MS, 1D and 2D NMR. The absolute configuration of compound 1 was confirmed by the CD experiment. All compounds were tested for nitric oxide (NO) inhibitory activity in vitro. The results showed that all compounds exhibited weak to moderate inhibition activities of NO production except compound 5.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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