Leishmanial activity of Brazilian brown propolis and its diterpenes.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-02 DOI:10.1080/14786419.2023.2277351

Larissa Costa Oliveira, Victor Pena Ribeiro, Mario Ferreira Conceição Santos, Nicoli Dias Oliveira, Matheus Henrique Marques Zago, Iaciara Luana de Xavier Albernaz, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães, Sérgio Ricardo Ambrósio

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Abstract

Propolis is a natural product widely used in folk medicine. Among its various applications, its antiparasitic properties stand out. Due to its great biodiversity, Brazil is a major producer of several types of propolis. This study proposes to evaluate the leishmanicidal properties of the hydroalcoholic extract of propolis collected in the southern region of Brazil (Brown propolis - HEBP) and its main isolated compounds: abietic acid (1), 13-epi-cupressic acid (2), 13-epi-torulosol (3), dehydroabietic acid (4), cis-communic acid (5) and ent-agatic acid (6). In general, the diterpenes did not show activity against the promastigotes of Leishmania (Leishmania) amazonensis at the evaluated concentrations. However, the HEBP was very active with an inhibition concentration of 50% at 8.32 µg/mL. Moreover, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) assays showed morphological and structural alterations in promastigote forms of L. (L.) amazonensis when incubated with HEBP.

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巴西棕蜂胶及其二萜的利什曼原虫活性。

蜂胶是一种广泛应用于民间医药的天然产品。在其各种应用中，其抗寄生虫特性尤为突出。由于其丰富的生物多样性，巴西是几种蜂胶的主要生产国。本研究旨在评价巴西南部地区采集的蜂胶水醇提取物（Brown propolis-HEBP）及其主要分离化合物：枞酸（1）、13-表铜酸（2）、13--表酮醇（3）、脱氢枞酸、顺式通讯酸（5）和龙舌兰酸（6）对利什曼原虫的杀灭性能。一般来说，在评估的浓度下，二萜对亚马逊利什曼原虫（Leishmania）的前鞭毛虫没有表现出活性。然而，HEBP非常活跃，在8.32时抑制浓度为50% µg/mL。此外，透射电子显微镜（TEM）和扫描电子显微镜（SEM）分析显示，当与HEBP孵育时，亚马逊乳杆菌的前鞭毛体形式发生了形态和结构变化。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.