Early adulthood weight change, midlife "Life's essential 8" health status and risk of cardiometabolic diseases: a chinese nationwide cohort study.

IF 3.9 2区 医学 Q2 NUTRITION & DIETETICS Nutrition & Metabolism Pub Date : 2023-11-01 DOI:10.1186/s12986-023-00765-w
Qiuyu Cao, Mian Li, Guijun Qin, Li Yan, Jiang He, Min Xu, Yu Xu, Tiange Wang, Yuhong Chen, Shuangyuan Wang, Hong Lin, Zhiyun Zhao, Zhengnan Gao, Tianshu Zeng, Ruying Hu, Xuefeng Yu, Gang Chen, Qing Su, Yiming Mu, Lulu Chen, Xulei Tang, Qin Wan, Guixia Wang, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Lixin Shi, Guang Ning, Weiqing Wang, Jieli Lu, Yufang Bi
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Abstract

Background: The association between weight change during early adulthood and cardiometabolic diseases remains uncertain in Chinese population. Whether the association varies with comprehensive cardiovascular health (CVH) in midlife assessed by "Life's Essential 8" has not been characterized. We aim to examine the associations of early adulthood weight change and midlife "Life's Essential 8" CVH status with cardiometabolic outcomes in a Chinese cohort.

Methods: The study participants were from the China Cardiometabolic Disease and Cancer Cohort (4 C) Study. This analysis included 72,610 middle-aged and older participants followed for a median of 3.6 years. At baseline, the participants recalled body weight at age 20 and 40 years, and we calculated change in weight and BMI between 20 and 40 years of age. Health behaviors information in "Life's Essential 8" was collected by questionnaire, and health factors were measured in the study center. During follow-up, we ascertained incident cardiovascular events based on medical records, and diagnosed incident diabetes according to the American Diabetes Association 2010 criteria.

Results: 72,610 study participants were included with a mean age of 56.0 ± 8.8 years and 29% of them were males. Weight gain of more than 10 kg between 20 and 40 years of age was associated with 22% increased risk of incident cardiovascular events (HR: 1.22; 95%CI: 1.04-1.43) and 38% increased risk of diabetes (HR: 1.38; 95%CI: 1.25-1.53) compared to stable weight. Besides, the association of weight gain more than 10 kg in early adulthood with cardiometabolic risk was even stronger in those with low CVH score in midlife (HR: 2.44; 95%CI: 2.01-2.97 for incident cardiovascular events; HR: 2.20; 95%CI: 1.90-2.55 for incident diabetes) or with few ideal cardiovascular health metrics in midlife.

Conclusions: Our study indicated that weight gain in early adulthood was associated with significantly increased risk of cardiometabolic diseases. And the association could be stronger in those with poor CVH profiles in midlife. These findings confirmed the significance of weight management during early adulthood and suggested that individuals who experienced substantial weight gain in early life should be encouraged to maintain good CVH status in Chinese population.

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成年早期体重变化、中年“生命必需8”健康状况和心脏代谢疾病风险:一项中国全国性队列研究。
背景:在中国人群中,成年早期体重变化与心脏代谢疾病之间的关系尚不确定。这种关联是否与“生命的基本8”评估的中年综合心血管健康(CVH)有关,目前尚未确定。我们的目的是在一个中国队列中研究成年早期体重变化和中年“生命必需8”CVH状态与心脏代谢结果的关系。方法:研究参与者来自中国心脏代谢疾病和癌症队列(4C)研究。该分析包括72610名中老年参与者,平均随访3.6年。在基线时,参与者回忆了20岁和40岁时的体重,我们计算了20岁到40岁之间体重和BMI的变化。采用问卷调查的方法收集《生活必需品8》中的健康行为信息,并在研究中心对健康因素进行测量。在随访期间,我们根据医疗记录确定了心血管事件,并根据美国糖尿病协会2010年的标准诊断为糖尿病。结果:72610名研究参与者,平均年龄56.0岁 ± 8.8岁,其中男性占29%。与稳定体重相比,20至40岁期间体重增加超过10公斤与心血管事件风险增加22%(HR:1.22;95%CI:1.04-1.43)和糖尿病风险增加38%(HR:1.38;95%CI:1.25-1.53)相关。此外,在中年CVH评分较低的人群中,成年早期体重增加超过10公斤与心脏代谢风险的相关性更强(HR:2.44;95%CI:2.01-2.97,针对心血管事件;HR:2.20;95%CI:1.90-2.55,针对糖尿病事件),或中年时几乎没有理想的心血管健康指标。结论:我们的研究表明,成年早期的体重增加与心脏代谢疾病的风险显著增加有关。在中年CVH状况不佳的人群中,这种联系可能会更强。这些发现证实了成年早期体重管理的重要性,并建议应鼓励早期体重大幅增加的人在中国人群中保持良好的CVH状态。
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来源期刊
Nutrition & Metabolism
Nutrition & Metabolism 医学-营养学
CiteScore
8.40
自引率
0.00%
发文量
78
审稿时长
4-8 weeks
期刊介绍: Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.
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