Progress in manufacturing and processing of degradable Fe-based implants: a review.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2022-06-01 Epub Date: 2022-05-18 DOI:10.1007/s40204-022-00189-4
V P Muhammad Rabeeh, T Hanas
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引用次数: 12

Abstract

Biodegradable metals have gained vast attention as befitting candidates for developing degradable metallic implants. Such implants are primarily employed for temporary applications and are expected to degrade or resorbed after the tissue is healed. Fe-based materials have generated considerable interest as one of the possible biodegradable metals. Like other biometals such as Mg and Zn, Fe exhibits good biocompatibility and biodegradability. The versatility in the mechanical behaviour of Fe-based materials makes them a better choice for load-bearing applications. However, the very low degradation rate of Fe in the physiological environment needs to be improved to make it compatible with tissue growth. Several studies on tailoring the degradation behaviour of Fe in the human body are already reported. Majority of these works include studies on the effect of manufacturing and processing techniques on biocompatibility and biodegradability. This article focuses on a comprehensive review and analysis of the various manufacturing and processing techniques so far reported for developing biodegradable iron-based orthopaedic implants. The current status of research in the field is neatly presented, and a summary of the works is included in the article for the benefit of researchers in the field to contextualise their research and effectively find the lacunae in the existing scholarship.

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可降解铁基植入物的制备和加工进展:综述。
可生物降解金属作为开发可降解金属植入物的合适候选者,受到了广泛关注。这种植入物主要用于临时应用,并且预期在组织愈合后降解或再吸收。铁基材料作为一种可能的可生物降解金属,引起了人们的极大兴趣。与镁和锌等其他生物金属一样,铁表现出良好的生物相容性和生物降解性。铁基材料机械性能的多功能性使其成为承载应用的更好选择。然而,Fe在生理环境中非常低的降解率需要提高,以使其与组织生长兼容。已经报道了几项关于调整铁在人体内降解行为的研究。这些工作中的大多数包括研究制造和加工技术对生物相容性和生物降解性的影响。本文重点对迄今为止报道的用于开发可生物降解铁基骨科植入物的各种制造和加工技术进行了全面的回顾和分析。文章巧妙地介绍了该领域的研究现状,并在文章中对这些工作进行了总结,以利于该领域的研究员将他们的研究背景化,并有效地发现现有学术中的空白。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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