[Cardiovascular calcifications in dialysis patients].

Pablo Ureña Torres, Charles Chazot
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Abstract

Patients with advanced chronic kidney disease and those already on dialysis have an increased prevalence of cardiovascular calcifications. They are the cause of severe complications and are associated with a reduced life expectancy in these patients. Recommendations and imaging scores have been developed to detect and assess their importance, to guide and improve the management of cardiovascular risk. However, despite these recommendations, current practice teaches us that they are only partially applied. The prevention and treatment of cardiovascular calcifications go through the correction of classic risk factors associated with atherosclerosis, mineral and bone metabolism disorders and by optimizing the dose and the efficiency of dialysis. New therapeutic strategies are beginning to emerge, others are being evaluated, such as sodium thiosulfate, rheopheresis, vitamin K, magnesium supplementation, and SNF-472.

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透析患者的心血管钙化
晚期慢性肾脏病患者和已经接受透析的患者心血管钙化的患病率增加。它们是严重并发症的原因,并与这些患者的预期寿命缩短有关。已经制定了建议和成像评分,以检测和评估其重要性,指导和改进心血管风险的管理。然而,尽管有这些建议,目前的做法告诉我们,这些建议只是部分适用。心血管钙化的预防和治疗需要纠正与动脉粥样硬化、矿物质和骨代谢紊乱相关的经典风险因素,并优化透析的剂量和效率。新的治疗策略开始出现,其他策略正在评估中,如硫代硫酸钠、流变学、维生素K、补充镁和SNF-472。
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