Gum-based Nanoparticles Targeting for Colon Rectal Cancer: Latest Research and Patents.

Shilpi Shakya, Ritesh Kumar Tiwari, Arti Gupta
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Abstract

Colorectal disease is the third most prevelant cancer in both men and women, with an expected 106,180 new cases of colon cancer and 44,850 new cases of rectal cancer as per American Cancer Society. Targeted medicine delivery is vital in the treatment of colon disorders because it delivers long-term therapeutic results with little side effects. Natural polymer is biocompatible and biodegradable, which enables safety, improves storage, and physiological stability, it is utilized as drug delivery vehicles and has made great strides in recent years. Chitosan, alginate, pectin, guar gum, dextran, hyaluronic acid, and arabinoxylan are examples of natural polysaccharides that are utilized to create nanoparticles. Natural gums serve two purposes: first, they shield the medicine from stomach and intestinal conditions, allowing it to only be released in the colon. In this review, we introduce the different gum particularly used in nanoparticles formulation, and then discuss recent research and the latest patent in the development of gum-based nanoparticles for the treatment of colon rectal cancer.

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靶向癌症的口香糖纳米粒子:最新研究和专利。
结直肠癌是男性和女性中发病率第三高的癌症,根据美国癌症协会的数据,预计癌症新增病例106180例,癌症新增病例44850例。靶向给药在结肠疾病的治疗中至关重要,因为它能带来长期的治疗效果,几乎没有副作用。天然聚合物具有生物相容性和生物可降解性,具有安全性、改善储存和生理稳定性,被用作药物递送载体,近年来取得了长足进步。壳聚糖、藻酸盐、果胶、瓜尔胶、右旋糖酐、透明质酸和阿拉伯木聚糖是用于制造纳米颗粒的天然多糖的例子。天然牙龈有两个用途:首先,它们保护药物免受胃肠道疾病的影响,使其只能在结肠中释放。在这篇综述中,我们介绍了不同的口香糖,特别是用于纳米颗粒配方,然后讨论了最近的研究和最新的专利在开发用于治疗结直肠癌癌症的口香糖纳米颗粒。
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