Selective estrogen receptor modulators and deep venous thrombosis after an emergent operation in senior women.

Pub Date : 2023-11-03 DOI:10.1186/s40981-023-00665-1

Keiko Kishida, Masanobu Furukawa, Masayuki Nakashima, Idumi Kubota, Yukio Hayashi

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Abstract

Background: Selective estrogen receptor modulators (SERMs), clinically applied to osteoporosis, may have potential risk of deep venous thrombosis (DVT) and discontinuation of SERMs may be required before surgery. However, we cannot discontinue SERMs for a certain duration, when patients undergo an emergent operation.

Case presentation: We reported two aged patients undergoing an emergent orthopedic surgery for lower extremities while taking SERMs for osteoporosis before the operation. DVT was newly developed in one patient and worsened in the other patient after the operation. We found eight aged patients underwent the same operation while taking SERMs for recent 3 years, including the two cases and DVT did not occur in the other six patients. Thus, the incidence of DVT in our patient population was 25%.

Conclusion: We showed that DVT developed or worsened after operation in two patients taking SERMs before operation. Ultrasound examination after operation may be recommended in these population. (149 words).

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选择性雌激素受体调节剂与老年妇女紧急手术后深静脉血栓形成。

背景：临床应用于骨质疏松症的选择性雌激素受体调节剂（SERMs）可能存在深静脉血栓形成（DVT）的潜在风险，手术前可能需要停用SERMs。然而，当患者接受紧急手术时，我们不能在一定时间内停止SERM。病例介绍：我们报告了两名老年患者在接受紧急下肢骨科手术时，在手术前服用SERMs治疗骨质疏松症。DVT在一名患者中是新出现的，另一名患者在手术后病情恶化。我们发现，近3年来，8名老年患者在服用SERM时接受了相同的手术，包括两例，其他6名患者没有发生DVT。因此，DVT在我们的患者群体中的发生率为25%。结论：我们发现两名术前服用SERM的患者在术后DVT发展或恶化。建议对这些人群进行术后超声检查。（149字）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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