The impact of mindfulness on working memory-related brain activation in breast cancer survivors with cognitive complaints.

IF 3.1 2区 医学 Q2 ONCOLOGY Journal of Cancer Survivorship Pub Date : 2025-04-01 Epub Date: 2023-11-03 DOI:10.1007/s11764-023-01484-0
Michelle Melis, Jeroen Blommaert, Katleen Van der Gucht, Ann Smeets, Brenna C McDonald, Stefan Sunaert, Andra Smith, Sabine Deprez
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Abstract

Purpose: Cancer-related cognitive impairment (CRCI) has been associated with altered brain activation after chemotherapy in areas related to working memory. Hence, improving working memory capacity and associated brain activation might aid in the recovery of CRCI. In this study, we investigated the potential of a mindfulness-based intervention (MBI) to impact working memory-related brain activation.

Methods: Female breast cancer survivors reporting cognitive complaints (N=117) were randomized into a mindfulness (n=43; MBI), physical training (n=36; PT), or waitlist control condition (n=38; WL). Participants completed MRI scans before the intervention, immediately after, and three months post-intervention. Task-based functional MRI was used to measure differences between groups over time in working memory-related brain activation while performing a visual-verbal n-back task.

Results: Data of 83 participants (32/26/25 MBI/PT/WL) was included. Compared to the waitlist group, MBI participants showed reduced task-related activation in the right middle frontal and angular gyrus and increased activation in the right dorsal posterior cingulate cortex over time. Compared to the physical training group, MBI participants showed reduced brain activation in the bilateral superior parietal lobule and right dorsal anterior cingulate cortex over time. No differences between physical training and no intervention were identified.

Conclusion: This study showed that an 8-week mindfulness-based intervention can significantly alter brain activation across brain regions involved in working memory, attentional control, and emotion processing during performance of a working memory task. This might aid in the recovery of CRCI.

Implications for cancer survivors: Mindfulness might alter brain activation patterns while performing a working memory task, which might ultimately aid in restoring higher order cognitive functions.

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正念对患有认知障碍的癌症乳腺癌幸存者工作记忆相关大脑激活的影响。
目的:癌症相关认知障碍(CRCI)与化疗后工作记忆相关区域的大脑激活改变有关。因此,提高工作记忆能力和相关的大脑激活可能有助于CRCI的恢复。在这项研究中,我们调查了基于正念的干预(MBI)对工作记忆相关大脑激活的影响。方法:报告认知障碍的癌症女性幸存者(N=117)被随机分为正念(N=43;MBI)、体能训练(N=36;PT)或等待控制状态(N=38;WL)。参与者在干预前、干预后立即和干预后三个月完成MRI扫描。基于任务的功能性MRI用于测量在执行视觉-语言n-背任务时,各组在工作记忆相关大脑激活方面随时间的差异。结果:纳入83名参与者(32/26/25 MBI/PT/WL)的数据。与等待名单组相比,随着时间的推移,MBI参与者右侧额中回和角回的任务相关激活减少,右侧背侧后扣带皮层的激活增加。与体能训练组相比,随着时间的推移,MBI参与者双侧顶上小叶和右背侧前扣带皮层的大脑激活减少。没有发现体育训练和没有干预之间的差异。结论:这项研究表明,为期8周的基于正念的干预可以显著改变工作记忆任务执行过程中涉及工作记忆、注意力控制和情绪处理的大脑区域的大脑激活。这可能有助于CRCI的恢复。对癌症幸存者的启示:正念可能会在执行工作记忆任务时改变大脑激活模式,这可能最终有助于恢复更高阶的认知功能。
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来源期刊
CiteScore
7.00
自引率
10.80%
发文量
149
审稿时长
>12 weeks
期刊介绍: Cancer survivorship is a worldwide concern. The aim of this multidisciplinary journal is to provide a global forum for new knowledge related to cancer survivorship. The journal publishes peer-reviewed papers relevant to improving the understanding, prevention, and management of the multiple areas related to cancer survivorship that can affect quality of care, access to care, longevity, and quality of life. It is a forum for research on humans (both laboratory and clinical), clinical studies, systematic and meta-analytic literature reviews, policy studies, and in rare situations case studies as long as they provide a new observation that should be followed up on to improve outcomes related to cancer survivors. Published articles represent a broad range of fields including oncology, primary care, physical medicine and rehabilitation, many other medical and nursing specialties, nursing, health services research, physical and occupational therapy, public health, behavioral medicine, psychology, social work, evidence-based policy, health economics, biobehavioral mechanisms, and qualitative analyses. The journal focuses exclusively on adult cancer survivors, young adult cancer survivors, and childhood cancer survivors who are young adults. Submissions must target those diagnosed with and treated for cancer.
期刊最新文献
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