Daylily (Hemerocallis fulva Linn.) flowers improve sleep quality in human and reduce nitric oxide and interleukin-6 production in macrophages.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.4103/cjop.CJOP-D-23-00043

Li-Min Hsu, Hua-Wei Chen, Po-Ching Wu, Kuo-Feng Hua

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Abstract

The flowers of daylily (Hemerocallis fulva Linn.) have been used as vegetable and medicinal herb for thousands of years in Taiwan and eastern Asia. Daylily flowers have been demonstrated to exert several biomedical properties. In this study, we provided the evidences show that daylily flowers exert anti-inflammatory activity in vitro and improved the sleep quality in vivo. We demonstrated that adult volunteers received water extract of daylily flowers improved sleep quality, sleep efficiency and daytime functioning, while sleep latency was reduced, compared to the adult volunteers received water. In addition, we demonstrated that aqueous and ethanol extracts of daylily flowers inhibited nitric oxide and interleukin-6 production in lipopolysaccharide-activated macrophages. Furthermore, the quantitative high performance liquid chromatography-based analysis showed the rutin content of the aqueous extract, ethanolic extract, ethyl acetate fractions of ethanolic extract, and water fractions of ethanolic extract were 7.27, 23.30, 14.71, and 57.43 ppm, respectively. These results indicate that daylily flowers have the potential to be a nutraceutical for improving inflammatory-related diseases and sleep quality in the future.

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萱草（Hemerocalis fulva Linn.）花可以改善人类的睡眠质量，并减少巨噬细胞中一氧化氮和白细胞介素-6的产生。

萱草花在台湾和东亚地区作为蔬菜和药材已有数千年的历史。睡莲花已被证明具有多种生物医学特性。在这项研究中，我们提供的证据表明，天花粉在体外发挥抗炎活性，并在体内改善睡眠质量。我们证明，与接受水的成年志愿者相比，接受黄花水提取物的成年志愿者改善了睡眠质量、睡眠效率和日间功能，同时降低了睡眠潜伏期。此外，我们还证明了黄花菜的水提取物和乙醇提取物抑制脂多糖激活的巨噬细胞中一氧化氮和白细胞介素-6的产生。此外，基于定量高效液相色谱的分析显示，水提取物、乙醇提取物、乙醇提取液的乙酸乙酯级分和乙醇提取物的水级分的芦丁含量分别为7.27、23.30、14.71和57.43ppm。这些结果表明，日花在未来有可能成为改善炎症相关疾病和睡眠质量的营养品。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.