Electrospun poly (ε-caprolactone)/beeswax based super-hydrophobic anti-adhesive nanofibers as physical barriers for impeding fibroblasts invasion.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL Journal of Biomaterials Applications Pub Date : 2023-11-01 Epub Date: 2023-11-05 DOI:10.1177/08853282231212604

B Sowmya, Prasanta Kumar Panda

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Abstract

Super-hydrophobic electrospun membranes are very essential barrier materials to physically isolate the wound site in order to prevent adhesions and for restoring the normal functioning of the surrounding tissues and organs. In the present study, poly (ε-caprolactone) (PCL)/beeswax (BW) based nanofibrous anti-adhesion membranes were fabricated by electrospinning technique. The BW concentration was varied from 10 to 30 wt.%. The nanofibers were evaluated for their morphological and physio-chemical properties. The electrospun mats demonstrate random distribution of nanofibers. Surface wettability was evaluated using static water contact angle method. PCL/BW (70/30) membrane had shown super-hydrophobicity (contact angle = 150°). From the cell culture studies, it was evident that cell viability, adhesion and proliferation of L929 cells on PCL/BW (70/30) membrane were comparatively lower than those on pure PCL membrane due to its super-hydrophobic nature. Consequently, PCL/BW (70/30) membrane was found as a potential candidate for fibroblast (L929) cell anti-adhesion applications.

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电纺聚（ε-己内酯）/蜂蜡基超疏水抗粘附纳米纤维作为阻碍成纤维细胞侵袭的物理屏障。

超疏水电纺膜是物理隔离伤口部位的非常重要的屏障材料，以防止粘连并恢复周围组织和器官的正常功能。本研究采用静电纺丝技术制备了聚ε-己内酯（PCL）/蜂蜡（BW）基纳米纤维防粘连膜。BW浓度在10-30wt.%之间变化。评估纳米纤维的形态和物理化学性质。电纺毡展示了纳米纤维的随机分布。采用静态水接触角法对表面润湿性进行了评价。PCL/BW（70/30）膜显示出超疏水性（接触角=150°）。从细胞培养研究中可以明显看出，L929细胞在PCL/BW（70/30）膜上的细胞活力、粘附和增殖由于其超疏水性而相对低于在纯PCL膜上的。因此，PCL/BW（70/30）膜被发现是成纤维细胞（L929）细胞抗粘附应用的潜在候选者。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.