Molecular Virology of SARS-CoV-2 and Related Coronaviruses.

IF 8 1区生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2022-06-15 Epub Date: 2022-03-28 DOI:10.1128/mmbr.00026-21

Yu-An Kung, Kuo-Ming Lee, Huan-Jung Chiang, Sheng-Yu Huang, Chung-Jung Wu, Shin-Ru Shih

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引用次数: 13

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to threaten the lives of hundreds of millions of people, with a severe negative impact on the global economy. Although several COVID-19 vaccines are currently being administered, none of them is 100% effective. Moreover, SARS-CoV-2 variants remain an important worldwide public health issue. Hence, the accelerated development of efficacious antiviral agents is urgently needed. Coronavirus depends on various host cell factors for replication. An ongoing research objective is the identification of host factors that could be exploited as targets for drugs and compounds effective against SARS-CoV-2. In the present review, we discuss the molecular mechanisms of SARS-CoV-2 and related coronaviruses, focusing on the host factors or pathways involved in SARS-CoV-2 replication that have been identified by genome-wide CRISPR screening.

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严重急性呼吸系统综合征冠状病毒2型和相关冠状病毒的分子病毒学。

2019冠状病毒病（新冠肺炎）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的。全球新冠肺炎疫情继续威胁着数亿人的生命，对全球经济造成严重负面影响。尽管目前正在接种几种新冠肺炎疫苗，但没有一种是100%有效的。此外，严重急性呼吸系统综合征冠状病毒2型变异株仍然是一个重要的全球公共卫生问题。因此，迫切需要加快开发有效的抗病毒药物。冠状病毒依赖于各种宿主细胞因子进行复制。一个正在进行的研究目标是识别宿主因子，这些宿主因子可以作为有效对抗严重急性呼吸系统综合征冠状病毒2型的药物和化合物的靶点。在这篇综述中，我们讨论了严重急性呼吸系统综合征冠状病毒2型和相关冠状病毒的分子机制，重点是通过全基因组CRISPR筛查确定的参与严重急性呼吸系综合征病毒2型复制的宿主因子或途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Molecular Biology Reviews 生物-微生物学

CiteScore

18.80

自引率

0.80%

发文量

期刊介绍： Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.