Two new Aspera chaetominines A and B, and a new derivative of terrein, isolated from marine sponge associated fungus Aspergillus versicolour SCSIO XWS04 F52

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2023.2275744

Mangaladoss Fredimoses , Wen Ai , Xiuping Lin , Xuefeng Zhou , Shengrong Liao , Li Pan , Yonghong Liu

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Abstract

Two new alkaloids, Aspera chaetominines A (1) and B (2), a new derivative (3) of terrein, and together with 11 known compounds (4–14) were isolated from marine sponge Callyspongia sp. -derived fungus Aspergillus versicolour SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of 1–3 were determined by spectroscopic (¹H, ¹³C NMR, HSQC, HMBC, and ¹H-¹H COSY), and MS analysis. Compounds 1 and 2 showed cytotoxic activity against leukaemia K562 and colon cancer cells SW1116 with IC₅₀ 7.5 to 12.5 μM, and also compounds 1 and 2 exhibited significant protection against H1N1 virus-induced cytopathogenicity in MDCK cells with IC₅₀ values of 15.5 and 24.5 μM, respectively.

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从海洋海绵相关真菌变色曲霉SCSIO XWS04 F52中分离出两种新的毛曲霉蛋白酶A和B，以及一种新的土霉素衍生物。

从海绵藻Callyspongia sp.中分离到两种新的生物碱，即毛曲霉毒素A（1）和B（2），一种新的土霉素衍生物（3），以及11种已知的化合物（4-14），并通过形态学和ITS序列分析对其进行了鉴定。1-3的平面结构通过光谱（1H、13C NMR、HSQC、HMBC和1H-1H COSY）和MS分析来确定。化合物1和2显示出对白血病K562和结肠癌细胞SW1116的细胞毒性活性，IC50为7.5至12.5 μM以及化合物1和2在MDCK细胞中对H1N1病毒诱导的细胞病变表现出显著的保护作用，IC50值分别为15.5和24.5 μM。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.