Organophosphorus poisoning induced delayed neurotoxicity: a report of two cases.

IF 0.9 Q4 CLINICAL NEUROLOGY Spinal Cord Series and Cases Pub Date : 2023-11-04 DOI:10.1038/s41394-023-00611-4

Amrutha Viswanath, Apurba Barman, Jagannatha Sahoo, Souvik Bhattacharjee, Suman Patel

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Abstract

Introduction: Organophosphorus compounds (OPC) are one of the most commonly used pesticides worldwide and are often misused for suicidal poisoning due to their easy availability. Acute manifestations and management of organophosphorus (OP) poisoning have been reported several times. Organophosphorus-induced delayed neurotoxicity (OPIDN) is a rare delayed presentation of OP poisoning that involves central-peripheral distal axonopathy.

Case presentation: In this study, we report two cases of OPIDN developed after a few weeks of OP poisoning. Clinical features, electrodiagnostic study findings, and rehabilitative measures adopted for the patients and their follow-up have been described in the report.

Discussion: Organophosphorus (OP) poisoning may rarely produce features of delayed neurotoxicity, which may gradually appear after acute cholinergic symptoms. This report shows the importance of considering the delayed presentation of possible OPC toxicity in patients with neurological symptoms and a history of OPC exposure.

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有机磷中毒引起的迟发性神经毒性：附2例报告。

简介：有机磷化合物（OPC）是世界上最常用的农药之一，由于其易于获得，经常被滥用用于自杀性中毒。有机磷（OP）中毒的急性表现和处理已多次报道。有机磷诱导的迟发性神经毒性（OPIDN）是一种罕见的迟发型OP中毒，涉及中枢-外周-远端轴突病变。病例介绍：在本研究中，我们报告了两例OP中毒数周后出现的OPIDN病例。报告中描述了患者的临床特征、电诊断研究结果、采取的康复措施及其随访情况。讨论：有机磷（OP）中毒可能很少产生延迟性神经毒性的特征，这种特征可能在急性胆碱能症状后逐渐出现。本报告显示了在有神经症状和OPC暴露史的患者中，考虑可能的OPC毒性延迟出现的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spinal Cord Series and Cases Medicine-Neurology (clinical)

CiteScore

2.20

自引率

8.30%

发文量