[Study of properties of three-dimensional matrices manufactured by antisolvent 3D printing for reconstruction of extensive bone defects in dentistry and maxillofacial surgery].

Q4 Medicine Stomatologiya Pub Date : 2023-01-01 DOI:10.17116/stomat202310205114
M A Khvorostina, V O Mokrousova, P Yu Algebraistova, I A Nedorubova, V S Kuznetsova, A A Kulakov
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引用次数: 0

Abstract

Objective: The aim of the study to study of physical, mechanical and biocompatible properties of the matrices manufactured by antisolvent 3D printing from the solutions of polylactide-co-glycolide in tetraglycol.

Material and methods: Three-dimensional scaffolds were made from a solution of polylactide-co-glycolide mixed with tetraglycol using antisolvent 3D printing. The elastic properties and the structure of the obtained matrices were studied. MTT-test and staining with PKH-26, Calcein-AM, DAPI with subsequent fluorescence microscopy were used to study biological properties.

Results: The three-dimensional scaffolds had good mechanical properties. Young's modulus value was 18±2 MPa, tensile strength was 0.43±0.05 MPa. The relative survival rate of cells after the first day was 99.58±2.28%, on the 14th day - 98.14±2.22%. The structure of the scaffold promoted cell adhesion and spreading on its surface.

Conclusion: The polylactide-co-glycolide matrices produced by antisolvent printing have high porosity, biocompatibility and good mechanical properties. It is allowed to use them in the future as a basis for personalized constructions for the replacement of extensive bone defects of the maxillofacial region.

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[通过抗溶剂3D打印制造的用于重建牙科和颌面外科中的广泛骨缺损的三维基质的性质的研究]。
目的:研究由聚乳酸-乙交酯在四甘醇中的溶液通过反溶剂3D打印制备的基质的物理、机械和生物相容性。材料和方法:采用抗溶剂3D打印技术,由聚乳酸-乙交酯与四甘醇的混合溶液制成三维支架。研究了所得基体的弹性性质和结构。MTT法和PKH-26、Calcein AM、DAPI染色及随后的荧光显微镜观察其生物学特性。结果:三维支架具有良好的力学性能。杨氏模量为18±2MPa,抗拉强度为0.43±0.05MPa。第一天后细胞的相对存活率为99.58±2.28%,第14天为98.14±2.22%。支架的结构促进了细胞在其表面的粘附和扩散。结论:抗溶剂印刷法制备的聚乳酸-乙交酯基质具有较高的孔隙率、生物相容性和良好的力学性能。允许在未来使用它们作为个性化结构的基础,以替换颌面部的广泛骨缺损。
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来源期刊
Stomatologiya
Stomatologiya Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
93
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