Stochastic organelle genome segregation through Arabidopsis development and reproduction

IF 8.3 1区 生物学 Q1 PLANT SCIENCES New Phytologist Pub Date : 2023-11-05 DOI:10.1111/nph.19288
Amanda K. Broz, Daniel B. Sloan, Iain G. Johnston
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拟南芥发育和繁殖过程中细胞器基因组的随机分离。
线粒体和质体中的组织器DNA(oDNA)对植物(和真核生物)生命至关重要。针对受损oDNA的选择在一定程度上是通过分离介导的——将不同的oDNA类型分类到种系中的不同细胞中。植物分离oDNA的速度非常快,oDNA重组蛋白MSH1是这种分离的关键驱动因素,但我们对植物内部和世代之间这种分离的动力学了解有限。在这里,我们揭示了oDNA是如何通过拟南芥的发育和繁殖进化的。我们将随机建模、贝叶斯推断和模型选择与通过发育和世代之间从异源拟南芥植物系中获得的新的和现有的组织特异性oDNA测量相结合。分离在植物发育过程中逐渐但持续地进行,在花序形成和下一代之间增加得更快。当MSH1受到损害时,大多数观察到的分离可以通过细胞分裂时的分离来实现。当MSH1具有功能时,mtDNA分离要快得多;我们发现oDNA基因转化率的增加是定量解释这种加速的一个合理机制。这些发现揭示了拟南芥oDNA分离的定量、时间依赖性细节。我们还讨论了这些观测结果对植物种系不同模型的支持。
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来源期刊
New Phytologist
New Phytologist 生物-植物科学
自引率
5.30%
发文量
728
期刊介绍: New Phytologist is an international electronic journal published 24 times a year. It is owned by the New Phytologist Foundation, a non-profit-making charitable organization dedicated to promoting plant science. The journal publishes excellent, novel, rigorous, and timely research and scholarship in plant science and its applications. The articles cover topics in five sections: Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology. These sections encompass intracellular processes, global environmental change, and encourage cross-disciplinary approaches. The journal recognizes the use of techniques from molecular and cell biology, functional genomics, modeling, and system-based approaches in plant science. Abstracting and Indexing Information for New Phytologist includes Academic Search, AgBiotech News & Information, Agroforestry Abstracts, Biochemistry & Biophysics Citation Index, Botanical Pesticides, CAB Abstracts®, Environment Index, Global Health, and Plant Breeding Abstracts, and others.
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