The Prognostic Value of Preoperative Naples Prognostic Score in Upper Tract Urothelial Carcinoma Patients after Radical Nephroureterectomy.

IF 2 4区医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI:10.1080/01635581.2023.2279218

Jianjun Ye, Zeyu Chen, Yulong Pan, Xinyang Liao, Xingyuan Wang, Chichen Zhang, Qihao Wang, Ping Han, Qiang Wei, Yige Bao

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Abstract

This study aims to determine the prognostic value of preoperative Naples prognostic score (NPS) on survival outcomes in upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU). We conducted a retrospective study about UTUC patients at West China Hospital from January 2015 to June 2019. The X-Tile program was used to identify the optimal cutoff value of NPS. Overall survival (OS), cancer-specific survival (CSS) and progression-free survival (PFS) were the endpoints of interest. Kaplan-Meier curves were used to estimate survival and Cox proportional hazard model was used for risk assessment. A total of 237 UTUC patients after RNU were identified and the threshold of NPS was determined to be 2. Preoperative high-NPS was associated with inferior OS (p = 0.004), CSS (p = 0.002) and PFS (p = 0.008), especially in locally advanced UTUC patients. Preoperative NPS was an independent predictor for OS (HR: 1.78; 95% CI: 1.08, 2.93), CSS (HR: 1.87; 95% CI: 1.11, 3.14) and PFS (HR: 1.60; 95% CI: 1.02, 2.50). The addition of NPS into the predictive model consisting of predictors from multivariate Cox regression resulted in better prediction performance. Preoperative NPS was a novel and reliable predictor for survival in UTUC patients after RNU, and should be further explored.

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Naples预后评分对上尿路上皮癌根治性肾输尿管切除术后患者的预后价值。

本研究旨在确定术前Naples预后评分（NPS）对上尿路上皮癌（UTUC）患者根治性肾输尿管切除术（RNU）后生存结果的预后价值。我们对2015年1月至2019年6月在华西医院就诊的UTUC患者进行了回顾性研究。X-Tile程序用于确定NPS的最佳截止值。总生存率（OS）、癌症特异性生存率（CSS）和无进展生存率（PFS）是感兴趣的终点。Kaplan-Meier曲线用于估计生存率，Cox比例风险模型用于风险评估。共有237名RNU后的UTUC患者被确定，NPS阈值被确定为2。术前高NPS与下OS相关（p = 0.004），CSS（p = 0.002）和PFS（p = 0.008），尤其是在局部晚期UTUC患者中。术前NPS是OS（HR:1.78；95%CI:1.082.93）、CSS（HR:1.87；95%CI:1.113.14）和PFS（HR:1.60；95%CI:1.022.50）的独立预测因子。在由多变量Cox回归预测因子组成的预测模型中添加NPS可获得更好的预测性能。术前NPS是一种新的、可靠的预测RNU后UTUC患者生存率的指标，值得进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.