An experimental study of consecutive administration of ropinirole and apomorphine for emesis induction in dogs

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES Journal of veterinary emergency and critical care Pub Date : 2023-11-09 DOI:10.1111/vec.13339

Lasse I. Saloranta DVM, Jouko M. Levijoki MSc, Arja M. Vuorela MSc

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Abstract

Objective

To study the safety and effectiveness of consecutively administered ropinirole and apomorphine (both dopamine 2-like receptor agonists) for emesis induction in dogs.

Design

Prospective, crossover study design.

Setting

Institutional animal research facility.

Animals

Six healthy male purpose-bred Beagle dogs.

Interventions

Each dog received 4 treatments: (1) apomorphine infusion (21 μg/kg) over 30 minutes + ropinirole eye drops (3.75 mg/m²); (2) ropinirole infusion (108 μg/m²) over 30 minutes + apomorphine SC (100 μg/kg); (3) apomorphine SC (100 μg/kg) + ropinirole eye drops (7.5 mg/m²) after 30 minutes; and (4) ropinirole eye drops (7.5 mg/m²) + apomorphine SC (100 μg/kg) after 30 minutes. Infusions were administered via a catheter instrumented in the cephalic vein. Eye drops and SC injections were administered as described in the product inserts. Blood samples were taken for ropinirole and apomorphine concentration analysis before dosing and periodically following administrations. The washout period between the treatments was 5–7 days.

Measurements and Main Results

Number of vomits and clinical signs were recorded. Alertness and heart rate were monitored in conjunction with blood sampling. The average number of vomits varied between 4.3 and 8.8 (range 1–16) following treatments. Signs of nausea, vomiting, and lethargy were seen in all individuals without significant differences between treatments. Moderate to marked, transient increase in heart rates was detected in all treatments. Infrequent noted side effects included ocular hyperemia, blepharospasms, and muscle tremors. Prior treatment with apomorphine significantly decreased the absorption of ropinirole eye drops.

Conclusions

The safety and efficacy profiles of this experimental study support that ropinirole and apomorphine could be administered consecutively in cases where the treatment using 1 substance has resulted in an incomplete evacuation of the stomach contents, and the attending veterinarian considers the use of a different agent to have benefits that outweigh the risks.

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罗哌洛尔和阿扑吗啡连续给药诱导犬呕吐的实验研究。

目的：研究连续给药罗哌洛尔和阿扑吗啡（均为多巴胺2受体激动剂）诱导犬呕吐的安全性和有效性。设计：前瞻性、交叉研究设计。设置：机构动物研究设施。动物：六只健康的雄性专门培育的比格犬。干预措施：每只狗接受4种治疗：（1）30分钟内输注阿扑吗啡（21μg/kg）+罗匹尼罗滴眼液（3.75 mg/m2）；（2）30分钟内输注罗哌洛尔（108μg/m2）+阿扑吗啡SC（100μg/kg）；（3）30分钟后，阿扑吗啡SC（100μg/kg）+罗匹尼罗滴眼液（7.5mg/m2）；（4）罗哌洛尔滴眼液（7.5mg/m2）+阿扑吗啡SC（100μ。通过头静脉内的导管进行输液。滴眼液和SC注射按照产品说明书中所述进行。在给药前和给药后定期采集血样进行罗匹尼罗和阿扑吗啡浓度分析。两次治疗之间的冲洗期为5-7天。测量和主要结果：记录呕吐次数和临床症状。在进行血液采样的同时监测警惕性和心率。治疗后呕吐物的平均数量在4.3到8.8之间（范围1-16）。所有患者均出现恶心、呕吐和嗜睡症状，两种治疗方法之间无显著差异。在所有治疗中都检测到心率的中度到显著的短暂增加。不常见的副作用包括眼部充血、眼睑痉挛和肌肉震颤。既往阿扑吗啡治疗显著降低了罗匹尼罗滴眼液的吸收。结论：本实验研究的安全性和有效性支持，在使用1种物质治疗导致胃内容物不完全排空的情况下，可以连续给药罗匹尼罗和阿扑吗啡，主治兽医认为使用不同的药物的益处大于风险。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.

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