The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease.

Keisuke Sawada, Hak Chung, Samir Softic, Maria E Moreno-Fernandez, Senad Divanovic
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Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor for end-stage liver diseases with no available therapies. Dysregulated immune responses are critical culprits of MASLD pathogenesis. Independent contributions from either the innate or adaptive arms of the immune system or their unidirectional interplay are commonly studied in MASLD. However, the bidirectional communication between innate and adaptive immune systems and its impact on MASLD remain insufficiently understood. Given that both innate and adaptive immune cells are indispensable for the development and progression of inflammation in MASLD, elucidating pathogenic contributions stemming from the bidirectional interplay between these two arms holds potential for development of novel therapeutics for MASLD. Here, we review the immune cell types and bidirectional pathways that influence the pathogenesis of MASLD and highlight potential pharmacologic approaches to combat MASLD based on current knowledge of this bidirectional crosstalk.

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代谢功能障碍相关脂肪变性肝病的双向免疫串扰。
代谢功能障碍相关的脂肪变性肝病(MASLD)是没有可用治疗方法的终末期肝病的一个不减的风险因素。失调的免疫反应是MASLD发病机制的关键因素。MASLD通常研究来自免疫系统固有或适应性臂的独立贡献或它们的单向相互作用。然而,先天免疫系统和适应性免疫系统之间的双向交流及其对MASLD的影响仍然没有得到充分的了解。鉴于先天免疫细胞和适应性免疫细胞对MASLD炎症的发展和进展都是不可或缺的,阐明这两个臂之间双向相互作用的致病作用具有开发MASLD新疗法的潜力。在这里,我们回顾了影响MASLD发病机制的免疫细胞类型和双向途径,并根据目前对这种双向串扰的了解,强调了对抗MASLD的潜在药理学方法。
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