Microfluidic-based nanoplatforms for cancer theranostic applications: A mini-review on recent advancements

Q2 Pharmacology, Toxicology and Pharmaceutics OpenNano Pub Date : 2023-10-31 DOI:10.1016/j.onano.2023.100197

Ali Bakhshi , Annu Pandey , Zelal Kharaba , Mahtab Razlansari , Saman Sargazi , Razieh Behzadmehr , Abbas Rahdar , Ana M. Díez-Pascual , Sonia Fathi-karkan

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Abstract

Cancer is amongst the foremost causes of death worldwide, and the field of nanotechnology presents promising prospects in terms of diagnostic and therapeutic approaches. Theranostics are nanoparticles (NPs) that possess the ability to combine therapeutic and diagnostic capabilities into a single agent. Nonetheless, the synthesis, characterization, and delivery of NPs for theranostics against cancer present obstacles. By providing swift, responsive, and economical platforms for cancer detection and treatment, microfluidic systems based on nanomaterials can overcome these obstacles. A synopsis of recent developments in microfluidic-assisted theranostic nanosystems for the treatment of various malignancies is provided in this mini-review. In addition to microfluidic system-based cancer sensing methods (optical, electrochemical, mechanical, and thermal), efficacious treatment approaches (gene therapy, drug delivery, sonodynamic therapy, etc.) are examined. Further, the potential and limitations of this innovative technique are analyzed, and its potential clinical applications in the future are proposed.

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基于微流体的纳米平台在癌症治疗中的应用:近期进展综述

癌症是世界上最主要的死亡原因之一，纳米技术领域在诊断和治疗方法方面具有很好的前景。Theranotics是一种纳米颗粒（NP），具有将治疗和诊断能力结合成单一药物的能力。尽管如此，用于治疗癌症的NP的合成、表征和递送仍然存在障碍。通过为癌症检测和治疗提供快速、响应灵敏和经济的平台，基于纳米材料的微流体系统可以克服这些障碍。本文简要介绍了用于治疗各种恶性肿瘤的微流体辅助治疗纳米系统的最新进展。除了基于微流体系统的癌症传感方法（光学、电化学、机械和热）外，还研究了有效的治疗方法（基因治疗、药物递送、声动力学治疗等）。进一步分析了这一创新技术的潜力和局限性，并提出了其未来潜在的临床应用前景。

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.