DNA on drugs

IF 0.5 Q4 GENETICS & HEREDITY Forensic Science International: Genetics Supplement Series Pub Date : 2022-12-01 DOI:10.1016/j.fsigss.2022.09.001

Amy Griffin , Paul Kirkbride , Julianne Henry , Ben Painter , Adrian Linacre

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Abstract

The use of illicit drugs is a continuing blight on society. Detecting DNA from individuals involved in the manufacturing and distribution of drugs can provide valuable investigative information or strategic intelligence which, in turn, can be used to disrupt the supply and distribution of illicit drugs. Our study details the transfer, persistence, prevalence, and recovery of human DNA on the exterior of tablets and capsules, as well as within drug powders. Various experiments were conducted to mimic stages in the creation and packaging of tablets and capsules. We showed that the act of brief contact (1–3 s) is sufficient to generate informative DNA profiles that can be uploaded and compared to databases internationally. This work complements chemical drug profiling data by linking seizures to each other and individuals via DNA profiles, providing information to prosecution or intelligence agencies. The generation of DNA information from illicit drug preparations is another tool that can be used in the fight against illicit drug manufacture and distribution.

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药物上的DNA

非法药物的使用对社会造成了持续的危害。从参与制造和分销毒品的个人身上检测DNA可以提供有价值的调查信息或战略情报，而这些信息或情报反过来又可以用来扰乱非法药物的供应和分销。我们的研究详细介绍了人类DNA在片剂和胶囊外以及药物粉末内的转移、持久性、流行率和回收率。进行了各种实验来模拟片剂和胶囊的生产和包装阶段。我们表明，短暂接触（1-3秒）就足以生成信息丰富的DNA图谱，这些图谱可以上传并与国际数据库进行比较。这项工作通过DNA图谱将缉获的毒品相互联系起来，并向检察机关或情报机构提供信息，从而补充了化学药物图谱数据。从非法药物制剂中生成DNA信息是可用于打击非法药物制造和分销的另一个工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Forensic Science International: Genetics Supplement Series Medicine-Pathology and Forensic Medicine

CiteScore

0.40

自引率

0.00%

发文量

122

审稿时长

25 days

期刊介绍： The Journal of Forensic Science International Genetics Supplement Series is the perfect publication vehicle for the proceedings of a scientific symposium, commissioned thematic issues, or for disseminating a selection of invited articles. The Forensic Science International Genetics Supplement Series is part of a duo of publications on forensic genetics, published by Elsevier on behalf of the International Society for Forensic Genetics.