Synthesis, crystal structure and antimicrobial activities of two silver(I) complexes based on bis(pyrazole) and carboxylic acid co-ligands

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Transition Metal Chemistry Pub Date : 2023-10-16 DOI:10.1007/s11243-023-00556-5

Hong Yang, Heng-Hui Zhang, Chang-Qing Li, Li-Jun Guo, Miao Yang, Tuo-Ping Hu

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Abstract

Two dinuclear and centrosymmetric silver-containing complexes, namely [Ag₂(3,5-dmpz)₂(3,5-dmpz methanol)₂(tbtc)] (1) and [Ag₂(3,5-dmpz)₂(3,5-dmpz methanol)₂(dbtc)] (2) (3,5-dmpz: dimethylpyrazole; 3,5-dmpz methanol: 3,5-dimethylpyrazole methanol; H₂tbtc: tetrabromoterephthalic acid; H₂dbtc: 2,5-dibromoterephthalic acid), were prepared and characterized. X-ray crystallographic data of 1 and 2 revealed that trigonal environment of the Ag ions has a “compressed Y’s” geometry. The antimicrobial activity of 1 and 2 was tested against the Gram-positive, Gram-negative bacteria and fungus, displaying the better inhibiting activity than the individual AgNO₃ and 3,5-dimethylpyrazole, especially for Candida albicans (IC₅₀ 2.5 ± 0.1 mg mL ⁻¹ and 2.8 ± 0.2 mg mL⁻¹). The quantified IC₅₀ values displayed that complexes 1 and 2 were more effective against fungus than the Gram-negative bacteria and Gram-positive bacteria.

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两种基于双（吡唑）和羧酸共配体的银（I）配合物的合成、晶体结构和抗菌活性

制备并表征了两种双核且中心对称的含银配合物，即[Ag2（3,5-dmpz）2（3,5-dmpz甲醇）2（tbtc）]（1）和[Ag2。1和2的X射线晶体学数据表明，Ag离子的三角环境具有“压缩的Y”几何结构。1和2对革兰氏阳性菌、革兰氏阴性菌和真菌的抗菌活性测试，显示出比单独的AgNO3和3，5-二甲基吡唑更好的抑制活性，尤其是对白色念珠菌的抑制活性（IC50 2.5 ± 0.1毫克毫升 −1和2.8 ± 0.2 mg mL−1）。定量的IC50值显示复合物1和2比革兰氏阴性菌和革兰氏阳性菌对真菌更有效。

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来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.