Cataractogenesis and molecular pathways, with reactive free oxygen species as a common pathway

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY Survey of ophthalmology Pub Date : 2024-03-01 DOI:10.1016/j.survophthal.2023.11.001
Arturo Iván Pérez Pacheco
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Abstract

Slowing down or stopping the natural process of cataractogenesis is certainly a challenge for those who today propose an option other than surgery. Addressing the same problem in different ways constitutes a new approach to solving what is today the number one cause of reversible blindness worldwide. The technological revolution, as well as the advances in the biological sciences, allows us to conceive mechanisms never thought of before to stop the process that, as a common pathway, constitutes opacification of the crystalline lens. A new dawn for cataracts is coming through molecular, newly-discovered mechanisms. Cataractogenesis and molecular pathways have reactive free oxygen species as a common pathway. Surgical removal is today's gold standard, but perhaps not for much longer.

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白内障发生和分子途径以活性游离氧为常见途径。
对于那些今天提出不同于手术选择的人来说,减缓或停止白内障形成的自然过程无疑是一个挑战。以不同的方式解决同一问题是解决当今世界可逆失明的头号原因的一种新方法。技术革命,以及不同科学的进步,使我们能够构想出以前从未想过的机制来阻止晶状体混浊的过程,这是一种常见的途径。通过新发现的分子机制,白内障迎来了新的曙光。白内障发生和分子途径中活性游离氧是一种常见的途径。手术切除是当今的黄金标准,但可能不会持续太久。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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