Antimicrobial and antitubercular activity of novel pyrazole-4-carboxamide derivatives: Synthesis and characterization

Abstract

The current research aims to identify the newest class of antifungal, antibacterial, and antitubercular lead compounds. Through the use of a carboxamide linkage, recent research has designed and synthesized a unique class of pyrazole-based molecular hybrids of aryl amines. Using a multistep method, the desired pyrazole carboxamide derivative was prepared. Compounds were characterized using 1 HNMR, C 13 NMR, and MASS spectral techniques. These substances were tested for their ability as antibacterial, antifungal, and antitubercular agents. All the compounds tested against Gram-positive and Gram-negative pathogens and fungal strains showed good antibacterial activity. Against Gram-positive pathogens, compound 5i showed potent activity, compound 5k demonstrated potent activity against Gram-negative strains, and compounds 5a, 5i, and 5j established potent activity against fungal strains and the Mycobacterium tuberculosis H37Rv strain.