Eugenio Hottz , Neal D. Tolley , Guy A. Zimmerman , Andrew S. Weyrich , Fernando A. Bozza
{"title":"Platelets in dengue infection","authors":"Eugenio Hottz , Neal D. Tolley , Guy A. Zimmerman , Andrew S. Weyrich , Fernando A. Bozza","doi":"10.1016/j.ddmec.2011.09.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>Dengue<span> has established itself as one of the world's most common mosquito-borne viral diseases. Although it prevails in tropical areas, sustained transmission of dengue has recently occurred in Florida. Dengue viruses<span> can induce a spectrum of symptoms and, in severe cases, mortality in approximately 1–5% of infected individuals. A hallmark of dengue infection is thrombocytopenia that associates with abnormal </span></span></span>platelet function, which is the focus of this review.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 1","pages":"Pages e33-e38"},"PeriodicalIF":0.0000,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.09.001","citationCount":"67","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676511000113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 67
Abstract
Dengue has established itself as one of the world's most common mosquito-borne viral diseases. Although it prevails in tropical areas, sustained transmission of dengue has recently occurred in Florida. Dengue viruses can induce a spectrum of symptoms and, in severe cases, mortality in approximately 1–5% of infected individuals. A hallmark of dengue infection is thrombocytopenia that associates with abnormal platelet function, which is the focus of this review.
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