{"title":"Functions of ADP-ribose transferases in the maintenance of telomere integrity.","authors":"Daniela Muoio, Natalie Laspata, Elise Fouquerel","doi":"10.1007/s00018-022-04235-z","DOIUrl":null,"url":null,"abstract":"<p><p>The ADP-ribose transferase (ART) family comprises 17 enzymes that catalyze mono- or poly-ADP-ribosylation, a post-translational modification of proteins. Present in all subcellular compartments, ARTs are implicated in a growing number of biological processes including DNA repair, replication, transcription regulation, intra- and extra-cellular signaling, viral infection and cell death. Five members of the family, PARP1, PARP2, PARP3, tankyrase 1 and tankyrase 2 are mainly described for their crucial functions in the maintenance of genome stability. It is well established that the most describedrole of PARP1, 2 and 3 is the repair of DNA lesions while tankyrases 1 and 2 are crucial for maintaining the integrity of telomeres. Telomeres, nucleoprotein complexes located at the ends of eukaryotic chromosomes, utilize their unique structure and associated set of proteins to orchestrate the mechanisms necessary for their own protection and replication. While the functions of tankyrases 1 and 2 at telomeres are well known, several studies have also brought PARP1, 2 and 3 to the forefront of telomere protection. The singular quality of the telomeric environment has highlighted protein interactions and molecular pathways distinct from those described throughout the genome. The aim of this review is to provide an overview of the current knowledge on the multiple roles of PARP1, PARP2, PARP3, tankyrase 1 and tankyrase 2 in the maintenance and preservation of telomere integrity.</p>","PeriodicalId":54439,"journal":{"name":"Systems Engineering","volume":"17 1","pages":"215"},"PeriodicalIF":1.6000,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964661/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Systems Engineering","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00018-022-04235-z","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, INDUSTRIAL","Score":null,"Total":0}
引用次数: 0
Abstract
The ADP-ribose transferase (ART) family comprises 17 enzymes that catalyze mono- or poly-ADP-ribosylation, a post-translational modification of proteins. Present in all subcellular compartments, ARTs are implicated in a growing number of biological processes including DNA repair, replication, transcription regulation, intra- and extra-cellular signaling, viral infection and cell death. Five members of the family, PARP1, PARP2, PARP3, tankyrase 1 and tankyrase 2 are mainly described for their crucial functions in the maintenance of genome stability. It is well established that the most describedrole of PARP1, 2 and 3 is the repair of DNA lesions while tankyrases 1 and 2 are crucial for maintaining the integrity of telomeres. Telomeres, nucleoprotein complexes located at the ends of eukaryotic chromosomes, utilize their unique structure and associated set of proteins to orchestrate the mechanisms necessary for their own protection and replication. While the functions of tankyrases 1 and 2 at telomeres are well known, several studies have also brought PARP1, 2 and 3 to the forefront of telomere protection. The singular quality of the telomeric environment has highlighted protein interactions and molecular pathways distinct from those described throughout the genome. The aim of this review is to provide an overview of the current knowledge on the multiple roles of PARP1, PARP2, PARP3, tankyrase 1 and tankyrase 2 in the maintenance and preservation of telomere integrity.
期刊介绍：
Systems Engineering is a discipline whose responsibility it is to create and operate technologically enabled systems that satisfy stakeholder needs throughout their life cycle. Systems engineers reduce ambiguity by clearly defining stakeholder needs and customer requirements, they focus creativity by developing a system’s architecture and design and they manage the system’s complexity over time. Considerations taken into account by systems engineers include, among others, quality, cost and schedule, risk and opportunity under uncertainty, manufacturing and realization, performance and safety during operations, training and support, as well as disposal and recycling at the end of life. The journal welcomes original submissions in the field of Systems Engineering as defined above, but also encourages contributions that take an even broader perspective including the design and operation of systems-of-systems, the application of Systems Engineering to enterprises and complex socio-technical systems, the identification, selection and development of systems engineers as well as the evolution of systems and systems-of-systems over their entire lifecycle.
Systems Engineering integrates all the disciplines and specialty groups into a coordinated team effort forming a structured development process that proceeds from concept to realization to operation. Increasingly important topics in Systems Engineering include the role of executable languages and models of systems, the concurrent use of physical and virtual prototyping, as well as the deployment of agile processes. Systems Engineering considers both the business and the technical needs of all stakeholders with the goal of providing a quality product that meets the user needs. Systems Engineering may be applied not only to products and services in the private sector but also to public infrastructures and socio-technical systems whose precise boundaries are often challenging to define.
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