Kinetics and mechanism of electrophilic substitution of heteroaromatic compounds. Part XXIII. Acid-catalysed hydrogen exchange of quinoline, isoquinoline, and their N-oxides
{"title":"Kinetics and mechanism of electrophilic substitution of heteroaromatic compounds. Part XXIII. Acid-catalysed hydrogen exchange of quinoline, isoquinoline, and their N-oxides","authors":"U. Bressel, A. Katritzky, J. Lea","doi":"10.1039/J29710000004","DOIUrl":null,"url":null,"abstract":"Rate profiles are reported for the title reactions. Exchanges are shown to proceed on the conjugate acid species at various positions in the carbocyclic rings. Exchange in the heterocyclic rings occurs by deprotonation α to nitrogen, and probably via covalent hydrated species β to nitrogen.","PeriodicalId":17268,"journal":{"name":"Journal of The Chemical Society B: Physical Organic","volume":"89 S1","pages":"4-10"},"PeriodicalIF":0.0000,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society B: Physical Organic","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/J29710000004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Rate profiles are reported for the title reactions. Exchanges are shown to proceed on the conjugate acid species at various positions in the carbocyclic rings. Exchange in the heterocyclic rings occurs by deprotonation α to nitrogen, and probably via covalent hydrated species β to nitrogen.
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