Forces, Chromosomal Configurations, and Carcinogenesis: Towards Another Therapeutic Approach

M. Lieber
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Abstract

Various types of forces, such as cohesive and adhesive forces, are involved in physical and biological processes. Many of these processes appear to have developmental features through different scales of nature, and such processes may reflect a universal dynamic of accommodation involving the universal dimensional constants. A particular avenue of plant tissue culture research, utilizing the process of electronic desaturation, might very well point to such a subsuming, universal process. Through the process of electronic desaturation of proteins in living cells, cohesive and adhesive forces are generated and regenerated between cellular proteins and between structured water and the proteins throughout and between mammalian cells. Those forces stabilize cells and tissues and prevent carcinogenesis [1,2]. In electronic desaturation, methylglyoxal-ascorbic acid complexes attach to particular protein regions, which enable or promote the conduction or movement of outer electrons of the proteins via methylglyoxal-ascorbic acid to oxygen. When such cohesive forces cease to exist in cells due to the conversion of methylglyoxal (MG) to D-lactic acid by glyoxalase, carcinogenesis ensues. Glyoxalase is an enzyme that can actively exist in cells. As noted by SzentGyorgyi [1,2], the presence of oxygen, MG, and ascorbic acid enabled the evolution of organisms with high levels of development and a general capability of preventing dedifferentiation that could lead to carcinogenesis.
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作用力、染色体构型和癌变:走向另一种治疗方法
物理和生物过程中涉及到各种类型的力,例如内聚力和粘附力。其中许多过程似乎具有不同自然尺度的发展特征,这些过程可能反映了涉及普遍维度常数的普遍适应动态。植物组织培养研究的一个特殊途径,利用电子去饱和过程,很可能指向这样一个包容的,普遍的过程。通过活细胞中蛋白质的电子脱饱和过程,细胞蛋白质之间、结构水与整个哺乳动物细胞中的蛋白质之间以及细胞之间产生和再生内聚力和黏附力。这些力量稳定细胞和组织,防止致癌[1,2]。在电子去饱和过程中,甲基乙二醛-抗坏血酸复合物附着在特定的蛋白质区域上,这使得或促进了蛋白质外层电子通过甲基乙二醛-抗坏血酸向氧的传导或移动。当这种凝聚力由于甲基乙二醛(MG)通过乙二醛酶转化为d -乳酸而在细胞中停止存在时,就会发生癌变。乙二醛酶是一种能在细胞中活跃存在的酶。正如SzentGyorgyi所指出的[1,2],氧气、MG和抗坏血酸的存在使生物体具有高水平发育的进化和防止可能导致致癌的去分化的一般能力。
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