Patient with Refractory Epilepsy Associated with Oligondendroglioma

Mauricio Vaillant Amarante, Ozinelia Pedroni Batista, Camilia Lampier Lutzke, Shirley Kempin Quiqui
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Abstract

Oligodendroglioma is a rare form of primary brain tumor, accounting for about 2-5% of intracranial tumors, being more common in adult males but rare in children, accounting for about 1-2% of all primary brain tumors in children. It originates from oligodendrocytes or glial precursor cells and exhibits infiltrative and slow growth. They can be classified in two grades (Grade II and Grade III), where Grade II are low grade tumors and have tumor cells that grow slowly and invade nearby normal tissue, and Grade III are malignant and have rapidly growing tumors. It has low growth and 50-80% of cases first symptom is seizures. A seizure is a symptom that requires a rapid solution usually requiring empirical treatment at the initial time to cease seizures and promote some well-being for the patient's routine. Seizures can cause a lot of damage to the patient's life, especially if the patient is a child who does not know what to do and what to do. Depending on the intensity and frequency of seizure episodes, the patient may experience fractures with falls, may suffer discrimination and prejudice at school. The causes behind refractory epilepsy are diverse, so whenever a patient is found to be refractory to drug treatment, the origin of seizures should be investigated early, it is not enough to stop at empirical treatment.
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伴少突胶质细胞瘤的难治性癫痫患者
少突神经胶质瘤是一种罕见的原发性脑肿瘤,约占颅内肿瘤的2-5%,多见于成年男性,在儿童中罕见,约占儿童原发性脑肿瘤的1-2%。它起源于少突胶质细胞或胶质前体细胞,具有浸润性,生长缓慢。可分为II级和III级,II级为低级别肿瘤,肿瘤细胞生长缓慢,侵袭附近正常组织;III级为恶性肿瘤,肿瘤生长迅速。它生长缓慢,50-80%的病例的第一症状是癫痫发作。癫痫发作是一种需要快速解决的症状,通常需要在最初进行经验性治疗以停止癫痫发作并促进患者日常生活的一些健康。癫痫发作会对患者的生活造成很大的伤害,特别是如果患者是一个不知道该怎么做和该怎么做的孩子。根据癫痫发作的强度和频率,患者可能会因跌倒而骨折,可能在学校受到歧视和偏见。难治性癫痫背后的原因是多种多样的,因此,每当发现患者对药物治疗难治性时,应及早调查癫痫发作的起源,仅止于经验性治疗是不够的。
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