Recent advances in the treatment of Malaria

S. Satish, Jayashree Puttur, E. Coutinho, P. Ambre, S. Nandan
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引用次数: 1

Abstract

Malaria is an infectious disease caused by protozoan parasites belonging to the Plasmodium species. The disease has been a major cause of mortality and morbidity, especially in populations of African and SouthEast Asian countries. A well-developed treatment regimen including the artemisinins as a potent antimalarial and other safety preventive measures have played a major role in reducing global burden of malaria over the years. However, recent reports of drug resistance against the artemisinins should be a wakeup call, for the artemisinins have been the mainstay towards the treatment of the disease in recent past. There is a need for newer antimalarials that can be active on more than one stage of the parasite life cycle. These may be complementary to the artemisinins and may also help in keeping a check on the menace of drug resistance. The current review focuses on clinical drug candidates with activity against more than one stages of the malarial parasite life cycle.
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疟疾治疗的最新进展
疟疾是一种由属于疟原虫的原生动物寄生虫引起的传染病。这种疾病是造成死亡和发病的主要原因,特别是在非洲和东南亚国家的人群中。多年来,完善的治疗方案,包括作为有效抗疟疾药物的青蒿素和其他安全预防措施,在减轻全球疟疾负担方面发挥了重要作用。然而,最近关于青蒿素耐药性的报告应该是一个警钟,因为青蒿素在最近一直是治疗该疾病的主要药物。需要能够在寄生虫生命周期的一个以上阶段起作用的新型抗疟药。这些可能是对青蒿素的补充,也可能有助于控制耐药性的威胁。目前的审查侧重于对疟疾寄生虫生命周期的一个以上阶段有活性的临床候选药物。
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