Q TRAP™ mass spectrometer technology for proteomics applications

Abstract

Mass spectrometry (MS) can play an important part in the characterization of protein posttranslational modifications. The specificity of triple-quadrupole scan modes combined with the sensitivity of the linear ion-trap operational modes in Q TRAP™ MS instruments presents new opportunities for automated investigation of posttranslational modifications in biological samples. The triple-quadrupole precursor ion and constant neutral loss scans are very powerful for identifying peptides that have been posttranslationally modified. In addition, the ion-trap product ion scans can provide valuable information for amino acid sequence determination and sites of modification.