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Genetic link to drug-induced weight gain identified 药物引起的体重增加与基因有关
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02463-6
Treasa Creavin
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引用次数: 0
The recombinant protein array: use in target identification and validation 重组蛋白阵列:用于目标识别和验证
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02460-0
Mark J. Schofield, Neil Sharma, Hui Ge

The human genome contains ∼30,000 genes, but it is proposed that these genes could encode up to a million different proteins. Alternative splicing of genes results in the same gene encoding for multiple proteins that can then undergo further transformation via various posttranslational modifications – it is a combination of these two processes that could lead to diversity in the proteins produced. Characterization of the interaction of proteins with each other, DNA and ligands remains an enormous challenge, particularly for traditional techniques that typically enable resolution of the interactions of a single protein. It is not surprising that the technologies that facilitate the direct and concurrent probing of all (or a significant subset of) the proteins of an organism have generated considerable interest from researchers and pharmaceutical companies alike. This review highlights new technologies available for the study of protein function, with a particular focus on the applications of recombinant protein arrays.

人类基因组包含约3万个基因，但有人提出这些基因可以编码多达100万种不同的蛋白质。基因的选择性剪接导致相同的基因编码多种蛋白质，然后可以通过各种翻译后修饰进行进一步的转化-这两个过程的结合可能导致产生的蛋白质的多样性。表征蛋白质之间的相互作用，DNA和配体仍然是一个巨大的挑战，特别是对于传统的技术，通常能够解决单个蛋白质的相互作用。这并不奇怪，促进直接和同时探测所有(或一个重要的子集)蛋白质的技术已经引起了研究人员和制药公司的相当大的兴趣。本文综述了用于蛋白质功能研究的新技术，重点介绍了重组蛋白质阵列的应用。
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引用次数: 2
The end of the beginning is nigh 开端的终结就在眼前
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02462-4
Henry Nicholls
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引用次数: 0
Pleiotropy: the BAFFling truth of the TNF superfamily 多效性:TNF超家族令人困惑的真相
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02457-0
Eugene A. Zhukovsky , Richard J. Morse
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引用次数: 0
Biomedical marker molecules for cancer – current status and perspectives 肿瘤生物医学标记分子研究现状与展望
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02459-4
Oliver Stoss, Thomas Henkel

Driven by the development of new techniques, such as DNA microarrays, mass spectroscopy, tissue microarrays or protein chips, a large number of biomarkers have been identified in the past few years with the aim to classify cancer subtypes or to predict disease progression or therapeutic response. However, few of the described markers have been developed into clinically validated diagnostic tools. This review provides an overview of recent cancer biomarker developments and the difficulties of moving biomarkers from basic research into the clinic.

在DNA微阵列、质谱、组织微阵列或蛋白质芯片等新技术发展的推动下，在过去几年中已经鉴定了大量生物标志物，目的是对癌症亚型进行分类或预测疾病进展或治疗反应。然而，所描述的标记物很少被开发成临床验证的诊断工具。这篇综述概述了最近癌症生物标志物的发展以及将生物标志物从基础研究转移到临床的困难。
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引用次数: 8
Ethics and patents: are patents bad or just misunderstood? 伦理与专利:专利是坏的还是被误解了?
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02461-2
D. Drysdale
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引用次数: 2
Ethics and patents: are patents bad or just misunderstood? 伦理与专利:专利是坏的还是被误解了?
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02461-2
Douglas Drysdale
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引用次数: 2
Functional protein microarrays for pathway mapping 功能蛋白微阵列的路径定位
Drug Discovery Today: TARGETS
Pub Date : 2004-12-01 DOI: 10.1016/S1741-8372(04)02458-2
Gregory A. Michaud, Rhonda Bangham, Michael Salcius, Paul F. Predki

Functional protein microarrays present an important new tool that is ideally suited to the mapping of biological pathways. Almost every basic feature of pathways, from binary and multi-component molecular interactions to enzymatic activity, has now been recapitulated and studied using protein microarrays. The generation of microarrays comprising whole proteomes of organisms will enable this technology to make significant contributions towards our understanding of disease pathways. We will review recent developments in functional protein microarrays, with a focus on their use for pathway mapping.

功能蛋白微阵列提供了一种重要的新工具，非常适合于绘制生物通路。几乎所有途径的基本特征，从二元和多组分分子相互作用到酶活性，现在已经用蛋白质微阵列重现和研究。由生物体的整个蛋白质组组成的微阵列的产生将使这项技术对我们对疾病途径的理解做出重大贡献。我们将回顾功能蛋白微阵列的最新发展，重点是它们在路径映射中的应用。
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引用次数: 6
Acetylcholine transporter could be muscular dystrophy's missing link 乙酰胆碱转运蛋白可能是肌肉萎缩症缺失的一环
Drug Discovery Today: TARGETS
Pub Date : 2004-10-01 DOI: 10.1016/S1741-8372(04)02455-7
Stephanie Sutherland
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引用次数: 0
Target identification and validation through genetics 通过遗传学鉴定和验证目标
Drug Discovery Today: TARGETS
Pub Date : 2004-10-01 DOI: 10.1016/S1741-8372(04)02450-8
Maxine J. Allen, Alisoun H. Carey

Drug target selection and validation is the goal of commercial genetic research. Human studies are beginning to deliver on their early promise of identifying complex disease susceptibility genes as the first step in validating potential new targets. Although the genes identified to date have shed light on some of the biological mechanisms that underlie complex disease, they have not always been tractable as drug targets. The current genetic strategies for disease gene identification are now being applied to specifically identify genetically associated drug targets in a high-throughput manner.

药物靶点的选择和验证是商业基因研究的目标。人类研究正开始实现其早期的承诺，即识别复杂的疾病易感基因，作为验证潜在新靶点的第一步。尽管迄今为止已确定的基因已经揭示了复杂疾病背后的一些生物学机制，但它们并不总是易于作为药物靶点。目前用于疾病基因鉴定的遗传策略正被应用于以高通量方式特异性地鉴定遗传相关的药物靶点。
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引用次数: 6
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